Matches in SemOpenAlex for { <https://semopenalex.org/work/W1991704903> ?p ?o ?g. }
- W1991704903 endingPage "66" @default.
- W1991704903 startingPage "55" @default.
- W1991704903 abstract "In addition to numerous GABA-ergic efferent neurons, the striatum contains a subpopulation of fast-firing GABA-ergic interneurons characterized by the presence of immunoreactivity for the calcium-binding protein, parvalbumin. Double-label in situ hybridization with digoxigenin- and radiolabelled cRNA probes was performed on striatal sections of adult rats to identify mRNAs expressed by striatal GABA-ergic interneurons. In the dorsolateral striatum, only parvalbumin mRNA-positive neurons expressed the mRNA encoding the potassium channel Kv3.1, a member of the Shaw family of potassium channels with rapid activation and inactivation kinetics, usually found in fast-firing neurons such as the basket cells of the hippocampus. Colocalization of the parvalbumin and Kv3.1 proteins was confirmed by double-label immunohistochemistry. Parvalbumin mRNA-positive neurons expressed very high levels of the mRNA encoding glutamic acid decarboxylase (Mr 67,000: GAD67) in the dorsolateral striatum. A smaller proportion of double-labelled neurons was found in the ventrolateral striatum. A small number of densely labelled neurons for GAD67 mRNA also expressed the mRNA encoding the dopamine D2 receptor, but none expressed detectable levels of the dopamine D1 receptor mRNA. This indicates major differences in the expression of dopamine receptor mRNA in a majority of GABA-ergic interneurons vs. GABA-ergic efferent neurons of the striatum. The results suggest that distinct molecular characteristics are associated with the distinct electrophysiological properties of striatal GABA-ergic neurons." @default.
- W1991704903 created "2016-06-24" @default.
- W1991704903 creator A5008896366 @default.
- W1991704903 creator A5028921090 @default.
- W1991704903 creator A5029830288 @default.
- W1991704903 creator A5053611329 @default.
- W1991704903 creator A5081762467 @default.
- W1991704903 date "1994-09-01" @default.
- W1991704903 modified "2023-10-14" @default.
- W1991704903 title "GABA-Ergic interneurons of the striatum express the shaw-like potassium channel KvS3.1" @default.
- W1991704903 cites W1041839862 @default.
- W1991704903 cites W1557172174 @default.
- W1991704903 cites W1616272027 @default.
- W1991704903 cites W1910271824 @default.
- W1991704903 cites W1965110152 @default.
- W1991704903 cites W1975404363 @default.
- W1991704903 cites W1979998480 @default.
- W1991704903 cites W1982470639 @default.
- W1991704903 cites W1996570128 @default.
- W1991704903 cites W2002227992 @default.
- W1991704903 cites W2002515081 @default.
- W1991704903 cites W2009197173 @default.
- W1991704903 cites W2012718212 @default.
- W1991704903 cites W2017067141 @default.
- W1991704903 cites W2018212332 @default.
- W1991704903 cites W2019062170 @default.
- W1991704903 cites W2035464530 @default.
- W1991704903 cites W2045629972 @default.
- W1991704903 cites W2051475820 @default.
- W1991704903 cites W2051973165 @default.
- W1991704903 cites W2052160175 @default.
- W1991704903 cites W2054731042 @default.
- W1991704903 cites W2055681098 @default.
- W1991704903 cites W2056807205 @default.
- W1991704903 cites W2057527559 @default.
- W1991704903 cites W2065145318 @default.
- W1991704903 cites W2074260855 @default.
- W1991704903 cites W2088928947 @default.
- W1991704903 cites W2089488135 @default.
- W1991704903 cites W2090124323 @default.
- W1991704903 cites W2091741039 @default.
- W1991704903 cites W2092246706 @default.
- W1991704903 cites W2093828787 @default.
- W1991704903 cites W2095545913 @default.
- W1991704903 cites W2095956820 @default.
- W1991704903 cites W2100793689 @default.
- W1991704903 cites W2101566513 @default.
- W1991704903 cites W2102193338 @default.
- W1991704903 cites W2115280754 @default.
- W1991704903 cites W2144693928 @default.
- W1991704903 cites W2157867342 @default.
- W1991704903 cites W961706964 @default.
- W1991704903 doi "https://doi.org/10.1002/syn.890180108" @default.
- W1991704903 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7825124" @default.
- W1991704903 hasPublicationYear "1994" @default.
- W1991704903 type Work @default.
- W1991704903 sameAs 1991704903 @default.
- W1991704903 citedByCount "90" @default.
- W1991704903 countsByYear W19917049032012 @default.
- W1991704903 countsByYear W19917049032013 @default.
- W1991704903 countsByYear W19917049032014 @default.
- W1991704903 countsByYear W19917049032015 @default.
- W1991704903 countsByYear W19917049032016 @default.
- W1991704903 countsByYear W19917049032017 @default.
- W1991704903 countsByYear W19917049032018 @default.
- W1991704903 countsByYear W19917049032019 @default.
- W1991704903 countsByYear W19917049032020 @default.
- W1991704903 countsByYear W19917049032021 @default.
- W1991704903 countsByYear W19917049032022 @default.
- W1991704903 countsByYear W19917049032023 @default.
- W1991704903 crossrefType "journal-article" @default.
- W1991704903 hasAuthorship W1991704903A5008896366 @default.
- W1991704903 hasAuthorship W1991704903A5028921090 @default.
- W1991704903 hasAuthorship W1991704903A5029830288 @default.
- W1991704903 hasAuthorship W1991704903A5053611329 @default.
- W1991704903 hasAuthorship W1991704903A5081762467 @default.
- W1991704903 hasConcept C126322002 @default.
- W1991704903 hasConcept C134018914 @default.
- W1991704903 hasConcept C141547260 @default.
- W1991704903 hasConcept C169760540 @default.
- W1991704903 hasConcept C17077164 @default.
- W1991704903 hasConcept C181199279 @default.
- W1991704903 hasConcept C2776512019 @default.
- W1991704903 hasConcept C2779263132 @default.
- W1991704903 hasConcept C2779296341 @default.
- W1991704903 hasConcept C2780062018 @default.
- W1991704903 hasConcept C40209533 @default.
- W1991704903 hasConcept C513476851 @default.
- W1991704903 hasConcept C55493867 @default.
- W1991704903 hasConcept C71924100 @default.
- W1991704903 hasConcept C86803240 @default.
- W1991704903 hasConcept C9497952 @default.
- W1991704903 hasConceptScore W1991704903C126322002 @default.
- W1991704903 hasConceptScore W1991704903C134018914 @default.
- W1991704903 hasConceptScore W1991704903C141547260 @default.
- W1991704903 hasConceptScore W1991704903C169760540 @default.
- W1991704903 hasConceptScore W1991704903C17077164 @default.
- W1991704903 hasConceptScore W1991704903C181199279 @default.