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• W1991708251 abstract "Generation of the p50 subunit of NF-kappaB is a rare case in which the ubiquitin system processes a longer precursor, p105, into a shorter active subunit: in the vast majority of cases, the target protein is completely degraded. The mechanisms involved in this process have remained elusive. It appears that a Gly rich region (GRR) in the middle of the molecule serves as a processing stop signal, though under certain conditions, such as after stimulation, p105 can be completely degraded. Since NF-kappaB plays critical roles in a broad array of basic cellular processes, it is important to dissect the mechanisms that regulate its proteolysis-both destruction and processing. We have previously shown that signal-induced degradation of p105 requires ubiquitination on multiple lysines. Here we describe a novel region, a Processing Inhibitory Domain-PID, that upon its removal, the molecule is processed in high efficiency, which requires ubiquitination on a single, though non-specific, lysine." @default.
• W1991708251 created "2016-06-24" @default.
• W1991708251 creator A5020940776 @default.
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• W1991708251 creator A5087180436 @default.
• W1991708251 date "2006-06-01" @default.
• W1991708251 modified "2023-09-27" @default.
• W1991708251 title "Two distinct ubiquitin-dependent mechanisms are involved in NF-κB p105 proteolysis" @default.
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• W1991708251 doi "https://doi.org/10.1016/j.bbrc.2006.04.036" @default.
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