Matches in SemOpenAlex for { <https://semopenalex.org/work/W1991708528> ?p ?o ?g. }
- W1991708528 endingPage "1126" @default.
- W1991708528 startingPage "1109" @default.
- W1991708528 abstract "Many antimicrobial agents have been associated with hypoprothrombinemia. The precise mechanisms are unknown, but alteration in vitamin K status or utilization is involved. The two postulated mechanisms implicate either direct inhibition of biosynthesis of the vitamin K-dependent clotting factors by the N-methylthiotetrazole (NMTT) moiety found in certain antimicrobial agents or eradication of vitamin K-producing intestinal microflora in patients with reduced oral intake of vitamin K. An English-language review of all prospective studies reported between 1966 and 1988 in which serial prothrombin times were monitored in adult patients revealed that the incidence of hypoprothrombinemia varied from 3.7% to 64% with NMTT-containing regimens and from 0% to 24% with non-NMTT-containing regimens. Detailed evaluation of these and other studies suggests that certain risk factors, including malnutrition, hepatic and renal dysfunction, older age, and severity of illness, may be the major determinants of hypoprothrombinemia. The hypothesis that the NMTT side chain is primarily responsible for hypoprothrombinemia may not be justified. We conclude that patients at high risk for coagulopathy should be carefully monitored and that serious consideration should be given to the use of prophylactic vitamin K in such cases." @default.
- W1991708528 created "2016-06-24" @default.
- W1991708528 creator A5022375796 @default.
- W1991708528 creator A5089536235 @default.
- W1991708528 date "1990-11-01" @default.
- W1991708528 modified "2023-09-26" @default.
- W1991708528 title "Antibiotic-Associated Hypoprothrombinemia: A Review of Prospective Studies, 1966–1988" @default.
- W1991708528 cites W1497330551 @default.
- W1991708528 cites W1511854710 @default.
- W1991708528 cites W1513776414 @default.
- W1991708528 cites W1526623443 @default.
- W1991708528 cites W1622035256 @default.
- W1991708528 cites W1760852900 @default.
- W1991708528 cites W1808902246 @default.
- W1991708528 cites W1932909252 @default.
- W1991708528 cites W1946933859 @default.
- W1991708528 cites W1964027757 @default.
- W1991708528 cites W1965752541 @default.
- W1991708528 cites W1967798505 @default.
- W1991708528 cites W1973151506 @default.
- W1991708528 cites W1984158272 @default.
- W1991708528 cites W1985637114 @default.
- W1991708528 cites W1990118546 @default.
- W1991708528 cites W1991966335 @default.
- W1991708528 cites W1994674007 @default.
- W1991708528 cites W2001764457 @default.
- W1991708528 cites W2001858964 @default.
- W1991708528 cites W2001966830 @default.
- W1991708528 cites W2007782598 @default.
- W1991708528 cites W2010322046 @default.
- W1991708528 cites W2011473088 @default.
- W1991708528 cites W2012126084 @default.
- W1991708528 cites W2014868622 @default.
- W1991708528 cites W2017720118 @default.
- W1991708528 cites W2019277359 @default.
- W1991708528 cites W2022319681 @default.
- W1991708528 cites W2023958925 @default.
- W1991708528 cites W2026855333 @default.
- W1991708528 cites W2026974583 @default.
- W1991708528 cites W2027541607 @default.
- W1991708528 cites W2029491587 @default.
- W1991708528 cites W2031069642 @default.
- W1991708528 cites W2031919408 @default.
- W1991708528 cites W2033098787 @default.
- W1991708528 cites W2034462617 @default.
- W1991708528 cites W2040384100 @default.
- W1991708528 cites W2042487313 @default.
- W1991708528 cites W2050140991 @default.
- W1991708528 cites W2053148108 @default.
- W1991708528 cites W2054553523 @default.
- W1991708528 cites W2056484891 @default.
- W1991708528 cites W2057287798 @default.
- W1991708528 cites W2061226328 @default.
- W1991708528 cites W2065024555 @default.
- W1991708528 cites W2065556640 @default.
- W1991708528 cites W2066277781 @default.
- W1991708528 cites W207049882 @default.
- W1991708528 cites W2073116072 @default.
- W1991708528 cites W2078231137 @default.
- W1991708528 cites W2080835429 @default.
- W1991708528 cites W2081028386 @default.
- W1991708528 cites W2081901522 @default.
- W1991708528 cites W2082782785 @default.
- W1991708528 cites W2097424134 @default.
- W1991708528 cites W2099205643 @default.
- W1991708528 cites W2102570523 @default.
- W1991708528 cites W2104897073 @default.
- W1991708528 cites W2119829487 @default.
- W1991708528 cites W2123533616 @default.
- W1991708528 cites W2132748540 @default.
- W1991708528 cites W2142022551 @default.
- W1991708528 cites W2153437842 @default.
- W1991708528 cites W2158704217 @default.
- W1991708528 cites W2159676408 @default.
- W1991708528 cites W2165671171 @default.
- W1991708528 cites W2179790871 @default.
- W1991708528 cites W2235374465 @default.
- W1991708528 cites W2241432584 @default.
- W1991708528 cites W2255152768 @default.
- W1991708528 cites W2316069082 @default.
- W1991708528 cites W2317407079 @default.
- W1991708528 cites W2326904335 @default.
- W1991708528 cites W2326959058 @default.
- W1991708528 cites W2331083322 @default.
- W1991708528 cites W2331676825 @default.
- W1991708528 cites W2332874251 @default.
- W1991708528 cites W2333723906 @default.
- W1991708528 cites W2336560803 @default.
- W1991708528 cites W2338855059 @default.
- W1991708528 cites W2377870242 @default.
- W1991708528 cites W2394479201 @default.
- W1991708528 cites W2394706240 @default.
- W1991708528 cites W2398730824 @default.
- W1991708528 cites W2401713846 @default.
- W1991708528 cites W2402365692 @default.
- W1991708528 cites W2410477000 @default.
- W1991708528 cites W2412966261 @default.
- W1991708528 cites W2416999678 @default.