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- W199171413 abstract "Publisher Summary Chronic NK cell lymphoproliferative disorder is characterized by a persistent increase in circulating NK cells. Microscopically, the cells are cytologically unremarkable with features typical of normal large granular lymphocytes. In keeping with this bland cytology, this disorder usually presents clinically either as an isolated laboratory finding with no associated signs or symptoms or with unexplained anaemia and/or neutropenia that are often quite mild. A minority of patients may have splenomegaly or more pronounced symptomatic cytopenias. Chronic NK cell lymphoproliferative disorder is typically found in adult patients but it has no recognized predilection for a particular age group, ethnic group, or gender. In addition, the disorder is not known to be specifically associated with any other diseases, although some cases may be encountered in patients with other hematopoietic neoplasms such as Hodgkin's lymphoma or multiple myeloma. Natural killer (NK) cell lineage lymphoproliferative disorders are, as a group, more recently described entities, particularly when compared to those of T and B cells. This in part is a reflection of the rarity of the disorders; however, it is also attributable to the challenges in establishing a diagnosis of NK cell malignancy in the clinical laboratory. These challenges vary depending on the nature of the NK cell disorder itself. For indolent processes it can be difficult to determine if the NK cells identified are truly abnormal, whereas in aggressive neoplasms it can be difficult to confidently ascribe NK cell lineage. In spite of such difficulties, a number of bona fide lymphoproliferative disorders of NK cells have been characterized. A total of four NK cell lymphoproliferative disorders and reactive NK cell lymphocytosis can be distinguished." @default.
- W199171413 created "2016-06-24" @default.
- W199171413 creator A5033163324 @default.
- W199171413 date "2010-01-01" @default.
- W199171413 modified "2023-09-23" @default.
- W199171413 title "Lymphoproliferative disorders of natural killer cells" @default.
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- W199171413 doi "https://doi.org/10.1016/b978-0-12-370454-2.00046-6" @default.
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