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• W1991719229 abstract "Activity, uptake and disposition of two related bisbiguanide antiseptics alexidine and chlorhexidine, were investigated. Rates of onset of membrane damage were faster following alexidine than chlorhexidine treatment. Deep-rough strains of E. coli were less sensitive than their smooth counterparts. Whilst the uptake of both agents to whole cells corresponded to ‘C-type’, alexidine demonstrated additional high affinity uptake (‘H-type’) at low applied drug concentrations. Distribution studies for the absorbed biocide indicated that the agents must saturate a number of envelope targets before penetration to the cytosol is possible. Alexidine possessed a higher affinity towards these sites than chlorhexidine." @default.
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• W1991719229 date "1989-10-01" @default.
• W1991719229 modified "2023-09-27" @default.
• W1991719229 title "Adsorption of alexidine and chlorhexidine to Escherichia coli and membrane components" @default.
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• W1991719229 doi "https://doi.org/10.1016/0378-5173(89)90043-4" @default.
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