Matches in SemOpenAlex for { <https://semopenalex.org/work/W1991722867> ?p ?o ?g. }
- W1991722867 endingPage "e1000106" @default.
- W1991722867 startingPage "e1000106" @default.
- W1991722867 abstract "Immunity to the murine cytomegalovirus (MCMV) is critically dependent on the innate response for initial containment of viral replication, resolution of active infection, and proper induction of the adaptive phase of the anti-viral response. In contrast to NK cells, the Valpha14 invariant natural killer T cell response to MCMV has not been examined. We found that Valpha14i NK T cells become activated and produce significant levels of IFN-gamma, but do not proliferate or produce IL-4 following MCMV infection. In vivo treatment with an anti-CD1d mAb and adoptive transfer of Valpha14i NK T cells into MCMV-infected CD1d(-/-) mice demonstrate that CD1d is dispensable for Valpha14i NK T cell activation. In contrast, both IFN-alpha/beta and IL-12 are required for optimal activation. Valpha14i NK T cell-derived IFN-gamma is partially dependent on IFN-alpha/beta but highly dependent on IL-12. Valpha14i NK T cells contribute to the immune response to MCMV and amplify NK cell-derived IFN-gamma. Importantly, mortality is increased in CD1d(-/-) mice in response to high dose MCMV infection when compared to heterozygote littermate controls. Collectively, these findings illustrate the plasticity of Valpha14i NK T cells that act as effector T cells during bacterial infection, but have NK cell-like behavior during the innate immune response to MCMV infection." @default.
- W1991722867 created "2016-06-24" @default.
- W1991722867 creator A5007707299 @default.
- W1991722867 creator A5071161157 @default.
- W1991722867 creator A5078725135 @default.
- W1991722867 creator A5083182033 @default.
- W1991722867 date "2008-07-18" @default.
- W1991722867 modified "2023-10-14" @default.
- W1991722867 title "NK Cell–Like Behavior of Vα14i NK T Cells during MCMV Infection" @default.
- W1991722867 cites W1495950501 @default.
- W1991722867 cites W1523753658 @default.
- W1991722867 cites W1560633399 @default.
- W1991722867 cites W1565511844 @default.
- W1991722867 cites W1593935815 @default.
- W1991722867 cites W1632817771 @default.
- W1991722867 cites W1799419298 @default.
- W1991722867 cites W1957245242 @default.
- W1991722867 cites W1969789349 @default.
- W1991722867 cites W1974408351 @default.
- W1991722867 cites W1977031008 @default.
- W1991722867 cites W1988573003 @default.
- W1991722867 cites W1992523113 @default.
- W1991722867 cites W2001383283 @default.
- W1991722867 cites W2003565653 @default.
- W1991722867 cites W2003568672 @default.
- W1991722867 cites W2004829503 @default.
- W1991722867 cites W2011988757 @default.
- W1991722867 cites W2015194963 @default.
- W1991722867 cites W2022273444 @default.
- W1991722867 cites W2025795383 @default.
- W1991722867 cites W2025843699 @default.
- W1991722867 cites W2030611349 @default.
- W1991722867 cites W2040393349 @default.
- W1991722867 cites W2041748137 @default.
- W1991722867 cites W2049678425 @default.
- W1991722867 cites W2057127638 @default.
- W1991722867 cites W2069556438 @default.
- W1991722867 cites W2072369136 @default.
- W1991722867 cites W2074238518 @default.
- W1991722867 cites W2076024275 @default.
- W1991722867 cites W2093041058 @default.
- W1991722867 cites W2095967285 @default.
- W1991722867 cites W2096726255 @default.
- W1991722867 cites W2118403212 @default.
- W1991722867 cites W2122582242 @default.
- W1991722867 cites W2123742933 @default.
- W1991722867 cites W2124491055 @default.
- W1991722867 cites W2134539007 @default.
- W1991722867 cites W2137075088 @default.
- W1991722867 cites W2139710737 @default.
- W1991722867 cites W2140009053 @default.
- W1991722867 cites W2144821901 @default.
- W1991722867 cites W2150998778 @default.
- W1991722867 cites W2151123418 @default.
- W1991722867 cites W2158257167 @default.
- W1991722867 cites W2162722910 @default.
- W1991722867 cites W2166807496 @default.
- W1991722867 cites W2167309621 @default.
- W1991722867 cites W4249939424 @default.
- W1991722867 cites W64458079 @default.
- W1991722867 doi "https://doi.org/10.1371/journal.ppat.1000106" @default.
- W1991722867 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2442879" @default.
- W1991722867 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18636102" @default.
- W1991722867 hasPublicationYear "2008" @default.
- W1991722867 type Work @default.
- W1991722867 sameAs 1991722867 @default.
- W1991722867 citedByCount "108" @default.
- W1991722867 countsByYear W19917228672012 @default.
- W1991722867 countsByYear W19917228672013 @default.
- W1991722867 countsByYear W19917228672014 @default.
- W1991722867 countsByYear W19917228672015 @default.
- W1991722867 countsByYear W19917228672016 @default.
- W1991722867 countsByYear W19917228672017 @default.
- W1991722867 countsByYear W19917228672018 @default.
- W1991722867 countsByYear W19917228672019 @default.
- W1991722867 countsByYear W19917228672020 @default.
- W1991722867 countsByYear W19917228672021 @default.
- W1991722867 countsByYear W19917228672022 @default.
- W1991722867 countsByYear W19917228672023 @default.
- W1991722867 crossrefType "journal-article" @default.
- W1991722867 hasAuthorship W1991722867A5007707299 @default.
- W1991722867 hasAuthorship W1991722867A5071161157 @default.
- W1991722867 hasAuthorship W1991722867A5078725135 @default.
- W1991722867 hasAuthorship W1991722867A5083182033 @default.
- W1991722867 hasBestOaLocation W19917228671 @default.
- W1991722867 hasConcept C129374314 @default.
- W1991722867 hasConcept C136449434 @default.
- W1991722867 hasConcept C139563560 @default.
- W1991722867 hasConcept C149532602 @default.
- W1991722867 hasConcept C154317977 @default.
- W1991722867 hasConcept C159047783 @default.
- W1991722867 hasConcept C193419808 @default.
- W1991722867 hasConcept C202751555 @default.
- W1991722867 hasConcept C203014093 @default.
- W1991722867 hasConcept C2776090121 @default.
- W1991722867 hasConcept C2778102761 @default.
- W1991722867 hasConcept C55493867 @default.
- W1991722867 hasConcept C86803240 @default.