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• W1991725363 abstract "Objectives: Stereotactic body radiation therapy (SBRT) is a technique used to deliver high, ablative doses of radiation in a limited number of fractions to ≥1 extracranial target(s). Although recent studies have shown that SBRT provides effective local tumor control in medically inoperable early-stage lung cancer patients, its implementation in clinical practice is unknown. Methods: A random sample of 1600 American radiation oncologists was surveyed regarding lung SBRT usage, including year adopted, most common prescription, respiratory motion management, and target localization. A biological equivalent dose (BED) was calculated using the linear quadratic model with α/β=10. Spearman rank correlation coefficients (rs) were calculated to identify factors associated with BED. Results: Of 1373 contactable physicians, 551 responses (40%) were received. Of 510 evaluable responses, 275 physicians (54%) reported using lung SBRT, over half of whom adopted it in 2008 or later. The most commonly reported prescriptions were 20 Gy×3 (22%), 18 Gy×3 (21%), and 12 Gy×4 (17%). Three fraction regimens were most common (48%), with nearly all (89%) prescribing ≥18 Gy/fraction. The median BED was 132 Gy, with 95% of reported prescriptions having BED≥100 Gy. Factors associated with increased BED included use of fiducial markers (rs=0.26, P<0.001), use of planar imaging (rs=0.18, P<0.01), and years of experience with lung SBRT (rs=0.13, P=0.04). Conclusions: Lung SBRT has rapidly become a widely adopted treatment approach in the United States with a range of varying implementations. Further research and additional prospective trials are necessary to optimize this novel approach." @default.
• W1991725363 created "2016-06-24" @default.
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• W1991725363 date "2013-06-01" @default.
• W1991725363 modified "2023-09-27" @default.
• W1991725363 title "Clinical Practice Patterns of Lung Stereotactic Body Radiation Therapy in the United States" @default.
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• W1991725363 doi "https://doi.org/10.1097/coc.0b013e3182467db3" @default.
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