Matches in SemOpenAlex for { <https://semopenalex.org/work/W1991726180> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W1991726180 endingPage "334" @default.
- W1991726180 startingPage "325" @default.
- W1991726180 abstract "Kinetic data for the lysozyme catalysed hydrolysis of aryl chitooligosides were surveyed. Both electron-donating and electron-withdrawing substituents on the departing aryl aglycones enhance the rate of hydrolyses. The parallel pH-rate profiles implicate that identical catalytic residues are involved in the hydrolytic fission of the glycosyl-aryloxy bond of these two groups of synthetic substrates. Molecular modelling studies of lysozyme complexes with aryl diN-acetyl chitobiosides and their intermediates were performed. The two synthetic substrates bearing aryl aglycones with opposite electronic effects bind to the active site of lysozyme in different conformations. Based on the energetic and geometric considerations, the oxocarbonium ion whose pyranose ring D in a sofa conformation is the most plausible reaction intermediate for the lysozyme catalysed hydrolysis of the synthetic substrates. The modelling study also suggests that considerable conformational changes of both the lysozyme binding site and the chitobiosyl group accompany the formation of the glycosyl enzyme intermediate. In particular, the chitobiosyl group undergoes a dislocation of the pyranose ring C from the subsite C and a constraint of the pyranose ring D to form a boat conformer." @default.
- W1991726180 created "2016-06-24" @default.
- W1991726180 creator A5057898039 @default.
- W1991726180 date "1997-02-01" @default.
- W1991726180 modified "2023-09-26" @default.
- W1991726180 title "Molecular modelling studies of lysozyme catalysed hydrolysis of synthetic substrates" @default.
- W1991726180 cites W1820694799 @default.
- W1991726180 cites W1889416338 @default.
- W1991726180 cites W1968938754 @default.
- W1991726180 cites W1982530655 @default.
- W1991726180 cites W1984970115 @default.
- W1991726180 cites W1996112440 @default.
- W1991726180 cites W2000584915 @default.
- W1991726180 cites W2010540464 @default.
- W1991726180 cites W2013038581 @default.
- W1991726180 cites W2016384087 @default.
- W1991726180 cites W2017784829 @default.
- W1991726180 cites W2029570920 @default.
- W1991726180 cites W2039337801 @default.
- W1991726180 cites W2040790510 @default.
- W1991726180 cites W2041167052 @default.
- W1991726180 cites W2050537942 @default.
- W1991726180 cites W2056876135 @default.
- W1991726180 cites W2060321485 @default.
- W1991726180 cites W2061618228 @default.
- W1991726180 cites W2064467953 @default.
- W1991726180 cites W2066243047 @default.
- W1991726180 cites W2073412555 @default.
- W1991726180 cites W2075999310 @default.
- W1991726180 cites W2077880778 @default.
- W1991726180 cites W2078617228 @default.
- W1991726180 cites W2081258375 @default.
- W1991726180 cites W2083385781 @default.
- W1991726180 cites W2090368251 @default.
- W1991726180 cites W2093959164 @default.
- W1991726180 cites W2162166182 @default.
- W1991726180 cites W2220462402 @default.
- W1991726180 cites W2228752616 @default.
- W1991726180 cites W2950469006 @default.
- W1991726180 cites W2950633309 @default.
- W1991726180 doi "https://doi.org/10.1016/s1357-2725(96)00106-9" @default.
- W1991726180 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9147134" @default.
- W1991726180 hasPublicationYear "1997" @default.
- W1991726180 type Work @default.
- W1991726180 sameAs 1991726180 @default.
- W1991726180 citedByCount "2" @default.
- W1991726180 countsByYear W19917261802016 @default.
- W1991726180 crossrefType "journal-article" @default.
- W1991726180 hasAuthorship W1991726180A5057898039 @default.
- W1991726180 hasConcept C178790620 @default.
- W1991726180 hasConcept C185592680 @default.
- W1991726180 hasConcept C2776966407 @default.
- W1991726180 hasConcept C2780263894 @default.
- W1991726180 hasConcept C2780378348 @default.
- W1991726180 hasConcept C2780906977 @default.
- W1991726180 hasConcept C2781076698 @default.
- W1991726180 hasConcept C34490408 @default.
- W1991726180 hasConcept C55493867 @default.
- W1991726180 hasConcept C71240020 @default.
- W1991726180 hasConcept C94412978 @default.
- W1991726180 hasConceptScore W1991726180C178790620 @default.
- W1991726180 hasConceptScore W1991726180C185592680 @default.
- W1991726180 hasConceptScore W1991726180C2776966407 @default.
- W1991726180 hasConceptScore W1991726180C2780263894 @default.
- W1991726180 hasConceptScore W1991726180C2780378348 @default.
- W1991726180 hasConceptScore W1991726180C2780906977 @default.
- W1991726180 hasConceptScore W1991726180C2781076698 @default.
- W1991726180 hasConceptScore W1991726180C34490408 @default.
- W1991726180 hasConceptScore W1991726180C55493867 @default.
- W1991726180 hasConceptScore W1991726180C71240020 @default.
- W1991726180 hasConceptScore W1991726180C94412978 @default.
- W1991726180 hasIssue "2" @default.
- W1991726180 hasLocation W19917261801 @default.
- W1991726180 hasLocation W19917261802 @default.
- W1991726180 hasOpenAccess W1991726180 @default.
- W1991726180 hasPrimaryLocation W19917261801 @default.
- W1991726180 hasRelatedWork W1991726180 @default.
- W1991726180 hasRelatedWork W1993702781 @default.
- W1991726180 hasRelatedWork W2021219953 @default.
- W1991726180 hasRelatedWork W2056862478 @default.
- W1991726180 hasRelatedWork W2067467788 @default.
- W1991726180 hasRelatedWork W2073924595 @default.
- W1991726180 hasRelatedWork W2074144279 @default.
- W1991726180 hasRelatedWork W2514488033 @default.
- W1991726180 hasRelatedWork W2766407610 @default.
- W1991726180 hasRelatedWork W2952833791 @default.
- W1991726180 hasVolume "29" @default.
- W1991726180 isParatext "false" @default.
- W1991726180 isRetracted "false" @default.
- W1991726180 magId "1991726180" @default.
- W1991726180 workType "article" @default.