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• W1991736636 abstract "The effects of a vitamin D deficiency on insulin and glucagon release was determined in the isolated perfused rat pancreas by radioimmunoassay of the secreted proteins. During a 30-minute period of perfusion with glucose and arginine, pancreases from vitamin D-deficient rats exhibited a 48 percent reduction in insulin secretion compared to that for pancreases from vitamin D-deficient rats that had been replenished with vitamin D. Vitamin D status had no effect on pancreatic glucagon secretion. This result, along with the previously demonstrated presence in the pancreas of a vitamin D-dependent calcium-binding protein and cytosol receptor for the hormonal form of vitamin D, 1,25-dihydroxyvitamin D3, indicates an important role for vitamin D in the endocrine functioning of the pancreas." @default.
• W1991736636 created "2016-06-24" @default.
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• W1991736636 date "1980-08-15" @default.
• W1991736636 modified "2023-10-01" @default.
• W1991736636 title "Vitamin D Deficiency Inhibits Pancreatic Secretion of Insulin" @default.
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• W1991736636 doi "https://doi.org/10.1126/science.6250216" @default.
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