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- W1991736795 abstract "The single nucleotide polymorphism p.N680S of the follicle-stimulating hormone (FSH) receptor (FSHR) is a discrete marker of ovarian response but previous in vitro studies failed to demonstrate differences in the response to FSH between N and S carrier cells. Here we demonstrate that p.N680S mediates different kinetics of the response to FSH in vitro. Intracellular cAMP production is faster in p.N680S N than in S homozygous human granulosa cells (45 versus 90 min to achieve the plateau, respectively; Mann–Whitney’s U-test; p < 0.005; n = 4). Reflecting the cAMP kinetics, phospho-ERK1/2 and -CREB activation, AREG and STARD1 gene expressions and progesterone production were qualitatively and quantitatively different in N versus S homozygous cells. Finally, the blockade of ERK pathway by U0126 abolishes the genotype-mediated different effects on gene expression and progesterone production (Mann–Whitney’s U-test; p ⩾ 0.005; n = 3)." @default.
- W1991736795 created "2016-06-24" @default.
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- W1991736795 date "2014-08-01" @default.
- W1991736795 modified "2023-10-14" @default.
- W1991736795 title "FSHR polymorphism p.N680S mediates different responses to FSH in vitro" @default.
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- W1991736795 doi "https://doi.org/10.1016/j.mce.2014.06.013" @default.
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