Matches in SemOpenAlex for { <https://semopenalex.org/work/W1991738304> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W1991738304 endingPage "151" @default.
- W1991738304 startingPage "143" @default.
- W1991738304 abstract "The immunohistochemical distribution of the epidermal proteins filaggrin, involucrin, and cytokeratins is characteristic in normal epidermis. This distribution may change as a result of malignant transformation or abnormal differentiation. The present study was conducted to determine the patterns of reactivity of psoriatic epidermis to antibodies against various epidermal proteins and to clarify abnormal differentiation or maturation of the keratinocytes in psoriatic epidermis. Anti-human filaggrin, anti-human involucrin, and twelve kinds of anti-cytokeratin antibodies were used in this study. Cryostat or paraffin-embedded sections were stained with these antibodies by the avidin-biotin peroxidase technique. The epidermis of the noninvolved skin of patients with psoriasis vulgaris showed the distribution seen in normal skin. However, involved psoriatic skin revealed little or no reaction in the stratum corneum or in the granular layer with the anti-filaggrin antibody. Cells positively staining with anti-involucrin antibody paradoxically appeared in the lower cell layers of involved psoriatic epidermis. An anti-keratin antibody, AE1, stained suprabasal cells in involved psoriatic epidermis, although this antibody selectively stained epidermal basal cells in normal skin. The other anti-keratin antibodies, especially KL1, PKK1, and a polyclonal anti-keratin antibody, were less reactive with involved psoriatic skin than with normal skin. These observations suggest that the maturation pathway of keratinocytes in active psoriatic lesions differs qualitatively from that in normal epidermis." @default.
- W1991738304 created "2016-06-24" @default.
- W1991738304 creator A5026258565 @default.
- W1991738304 creator A5067857002 @default.
- W1991738304 creator A5072424866 @default.
- W1991738304 creator A5084081288 @default.
- W1991738304 date "1991-03-01" @default.
- W1991738304 modified "2023-10-18" @default.
- W1991738304 title "Abnormal Distribution of Epidermal Protein Antigens in Psoriatic Epidermis" @default.
- W1991738304 cites W1965984529 @default.
- W1991738304 cites W1969356752 @default.
- W1991738304 cites W1975018777 @default.
- W1991738304 cites W1977882189 @default.
- W1991738304 cites W1983280412 @default.
- W1991738304 cites W1996513552 @default.
- W1991738304 cites W2007125729 @default.
- W1991738304 cites W2011699709 @default.
- W1991738304 cites W2016693266 @default.
- W1991738304 cites W2020088099 @default.
- W1991738304 cites W2031043837 @default.
- W1991738304 cites W2031443533 @default.
- W1991738304 cites W2035388701 @default.
- W1991738304 cites W2053710817 @default.
- W1991738304 cites W2066376199 @default.
- W1991738304 cites W2071499843 @default.
- W1991738304 cites W2081743971 @default.
- W1991738304 doi "https://doi.org/10.1111/j.1346-8138.1991.tb03057.x" @default.
- W1991738304 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1715894" @default.
- W1991738304 hasPublicationYear "1991" @default.
- W1991738304 type Work @default.
- W1991738304 sameAs 1991738304 @default.
- W1991738304 citedByCount "61" @default.
- W1991738304 countsByYear W19917383042012 @default.
- W1991738304 countsByYear W19917383042013 @default.
- W1991738304 countsByYear W19917383042014 @default.
- W1991738304 countsByYear W19917383042015 @default.
- W1991738304 countsByYear W19917383042016 @default.
- W1991738304 countsByYear W19917383042020 @default.
- W1991738304 countsByYear W19917383042021 @default.
- W1991738304 crossrefType "journal-article" @default.
- W1991738304 hasAuthorship W1991738304A5026258565 @default.
- W1991738304 hasAuthorship W1991738304A5067857002 @default.
- W1991738304 hasAuthorship W1991738304A5072424866 @default.
- W1991738304 hasAuthorship W1991738304A5084081288 @default.
- W1991738304 hasConcept C105702510 @default.
- W1991738304 hasConcept C142724271 @default.
- W1991738304 hasConcept C159654299 @default.
- W1991738304 hasConcept C190684412 @default.
- W1991738304 hasConcept C202751555 @default.
- W1991738304 hasConcept C203014093 @default.
- W1991738304 hasConcept C204232928 @default.
- W1991738304 hasConcept C2776458125 @default.
- W1991738304 hasConcept C2777074287 @default.
- W1991738304 hasConcept C2777577635 @default.
- W1991738304 hasConcept C2778329239 @default.
- W1991738304 hasConcept C2778370115 @default.
- W1991738304 hasConcept C2780564577 @default.
- W1991738304 hasConcept C55493867 @default.
- W1991738304 hasConcept C71924100 @default.
- W1991738304 hasConcept C81241287 @default.
- W1991738304 hasConcept C86803240 @default.
- W1991738304 hasConceptScore W1991738304C105702510 @default.
- W1991738304 hasConceptScore W1991738304C142724271 @default.
- W1991738304 hasConceptScore W1991738304C159654299 @default.
- W1991738304 hasConceptScore W1991738304C190684412 @default.
- W1991738304 hasConceptScore W1991738304C202751555 @default.
- W1991738304 hasConceptScore W1991738304C203014093 @default.
- W1991738304 hasConceptScore W1991738304C204232928 @default.
- W1991738304 hasConceptScore W1991738304C2776458125 @default.
- W1991738304 hasConceptScore W1991738304C2777074287 @default.
- W1991738304 hasConceptScore W1991738304C2777577635 @default.
- W1991738304 hasConceptScore W1991738304C2778329239 @default.
- W1991738304 hasConceptScore W1991738304C2778370115 @default.
- W1991738304 hasConceptScore W1991738304C2780564577 @default.
- W1991738304 hasConceptScore W1991738304C55493867 @default.
- W1991738304 hasConceptScore W1991738304C71924100 @default.
- W1991738304 hasConceptScore W1991738304C81241287 @default.
- W1991738304 hasConceptScore W1991738304C86803240 @default.
- W1991738304 hasIssue "3" @default.
- W1991738304 hasLocation W19917383041 @default.
- W1991738304 hasLocation W19917383042 @default.
- W1991738304 hasOpenAccess W1991738304 @default.
- W1991738304 hasPrimaryLocation W19917383041 @default.
- W1991738304 hasRelatedWork W1982291330 @default.
- W1991738304 hasRelatedWork W2038446823 @default.
- W1991738304 hasRelatedWork W2058882213 @default.
- W1991738304 hasRelatedWork W2058942017 @default.
- W1991738304 hasRelatedWork W2061061042 @default.
- W1991738304 hasRelatedWork W2077558523 @default.
- W1991738304 hasRelatedWork W2108404296 @default.
- W1991738304 hasRelatedWork W2465939324 @default.
- W1991738304 hasRelatedWork W35840514 @default.
- W1991738304 hasRelatedWork W92480293 @default.
- W1991738304 hasVolume "18" @default.
- W1991738304 isParatext "false" @default.
- W1991738304 isRetracted "false" @default.
- W1991738304 magId "1991738304" @default.
- W1991738304 workType "article" @default.