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• W1991744602 endingPage "2892" @default.
• W1991744602 startingPage "2884" @default.
• W1991744602 abstract "The ATP-Binding Cassette (ABC) superfamily is the largest transporter family known to translocate a wide variety of exogenous and endogenous substrates across cell membranes. In this chapter we review the potential role of three ABC proteins in the transport of unconjugated bilirubin (UCB). These transporters are MRP1, MRP3 and PGP (MDR1). MRP1 is expressed at high levels in most epithelia, usually at the basolateral membrane. Among a multiplicity of substrates, MRP1 mediates the ATP-dependent cellular export of UCB, and its role has been demonstrated in protecting cells from UCB toxicity. MRP3 is an organic anion transporter whose major substrates are GSH conjugates of organic compounds. Among the MRP family members, MRP3 shares the highest degree of amino acid homology with MRP1. Although the hepatic expression of MRP3 has been reported to be up-regulated by bilirubin and bilirubin glucuronides, it is unknown whether MRP3 is also involved in the transport of UCB. PGP is expressed in organs involved in the elimination of endo- and xenobiotics and UCB is one of these substrates. Since the Km of PGP for UCB is well above pathophysiological levels of Bf, it remains uncertain whether it has a role in protecting against UCB cytotoxicity. Keywords: ATP-binding-cassette protein (ABC) protein, multidrug-resistance-associated protein 1 (MRP1), multidrugresistance-associated protein 3 (MRP3), P-glycoprotein (PGP), unconiugated bilirubin, bilirubin neurocytotoxicity" @default.
• W1991744602 created "2016-06-24" @default.
• W1991744602 creator A5063803893 @default.
• W1991744602 creator A5067375384 @default.
• W1991744602 creator A5071646464 @default.
• W1991744602 date "2009-09-01" @default.
• W1991744602 modified "2023-09-26" @default.
• W1991744602 title "The Role of ABC Transporters in Protecting Cells from Bilirubin Toxicity" @default.
• W1991744602 cites W109378212 @default.
• W1991744602 cites W1523695341 @default.
• W1991744602 cites W1559057202 @default.
• W1991744602 cites W1570865673 @default.
• W1991744602 cites W1576138947 @default.
• W1991744602 cites W1580386589 @default.
• W1991744602 cites W1647335295 @default.
• W1991744602 cites W1733159128 @default.
• W1991744602 cites W1768069605 @default.
• W1991744602 cites W1868530020 @default.
• W1991744602 cites W1890023926 @default.
• W1991744602 cites W1908587496 @default.
• W1991744602 cites W1911655428 @default.
• W1991744602 cites W1938519122 @default.
• W1991744602 cites W1964604991 @default.
• W1991744602 cites W1965129145 @default.
• W1991744602 cites W1966052609 @default.
• W1991744602 cites W1969420116 @default.
• W1991744602 cites W1984613701 @default.
• W1991744602 cites W1985569822 @default.
• W1991744602 cites W1986874510 @default.
• W1991744602 cites W1992475433 @default.
• W1991744602 cites W1997863649 @default.
• W1991744602 cites W2003110351 @default.
• W1991744602 cites W2003334133 @default.
• W1991744602 cites W2011307851 @default.
• W1991744602 cites W2012607246 @default.
• W1991744602 cites W2019118443 @default.
• W1991744602 cites W2021213789 @default.
• W1991744602 cites W2021759214 @default.
• W1991744602 cites W2025229357 @default.
• W1991744602 cites W2026390217 @default.
• W1991744602 cites W2028533496 @default.
• W1991744602 cites W2030036139 @default.
• W1991744602 cites W2041768893 @default.
• W1991744602 cites W2050494872 @default.
• W1991744602 cites W2050767064 @default.
• W1991744602 cites W2051396617 @default.
• W1991744602 cites W2052325851 @default.
• W1991744602 cites W2053706150 @default.
• W1991744602 cites W2054846013 @default.
• W1991744602 cites W2055552041 @default.
• W1991744602 cites W2056647420 @default.
• W1991744602 cites W2058093850 @default.
• W1991744602 cites W2058189913 @default.
• W1991744602 cites W2067558825 @default.
• W1991744602 cites W2072069374 @default.
• W1991744602 cites W2073885483 @default.
• W1991744602 cites W2074274895 @default.
• W1991744602 cites W2076536269 @default.
• W1991744602 cites W2081126191 @default.
• W1991744602 cites W2087796453 @default.
• W1991744602 cites W2088181512 @default.
• W1991744602 cites W2090910729 @default.
• W1991744602 cites W2092118786 @default.
• W1991744602 cites W2092765737 @default.
• W1991744602 cites W2100150770 @default.
• W1991744602 cites W2101686121 @default.
• W1991744602 cites W2103467580 @default.
• W1991744602 cites W2110118559 @default.
• W1991744602 cites W2112001901 @default.
• W1991744602 cites W2112020079 @default.
• W1991744602 cites W2113122192 @default.
• W1991744602 cites W2113581854 @default.
• W1991744602 cites W2115541046 @default.
• W1991744602 cites W2118234018 @default.
• W1991744602 cites W2119471148 @default.
• W1991744602 cites W2122969043 @default.
• W1991744602 cites W2124335825 @default.
• W1991744602 cites W2125809720 @default.
• W1991744602 cites W2127275856 @default.
• W1991744602 cites W2127568511 @default.
• W1991744602 cites W2136374939 @default.
• W1991744602 cites W2140744545 @default.
• W1991744602 cites W2142030049 @default.
• W1991744602 cites W2148776940 @default.
• W1991744602 cites W2151625463 @default.
• W1991744602 cites W2152671837 @default.
• W1991744602 cites W2153338237 @default.
• W1991744602 cites W2157199556 @default.
• W1991744602 cites W2157666185 @default.
• W1991744602 cites W2159908530 @default.
• W1991744602 cites W2160748238 @default.
• W1991744602 cites W2165016043 @default.
• W1991744602 cites W2168070336 @default.
• W1991744602 cites W2171106895 @default.
• W1991744602 cites W2182243624 @default.
• W1991744602 cites W2190720904 @default.
• W1991744602 cites W2264883746 @default.
• W1991744602 cites W2290695793 @default.

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