Matches in SemOpenAlex for { <https://semopenalex.org/work/W1991745858> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W1991745858 endingPage "237" @default.
- W1991745858 startingPage "230" @default.
- W1991745858 abstract "Abstract We have presented a structural model of the chromosome based on its constituent proteins. Development of a method of mass isolation for intact human metaphase chromosomes and proteome analysis by mass spectrometry of the isolated chromosomal proteins enabled us to develop a four‐layer structural model of human metaphase chromosomes. The model consists of four layers, each with different chromosomal protein sets, i.e., chromosome coating proteins (CCPs), chromosome peripheral proteins (CPPs), chromosome structural proteins (CSPs), and chromosome fibrous proteins (CFPs). More than 200 identified proteins have been classified and assigned to the four layers with each layer occupying a distinct region of the chromosome. CCPs are localized at the most outer regions of the chromosomes and they attach to the regions tentatively and occasionally. CCPs include mostly mitochondrial and cytoplasmic proteins, e.g., 70 kDa heat shock protein 9B and Hsp60. CPPs are also localized at the peripheral regions of the chromosomes, but as the essential part of the chromosomes. CPPs include nucleolin, lamin A/C, fibrillarin, etc. CSPs are the primary chromosomal structure proteins, and include topoisomerase IIα, condensin subunits, histones, etc. CFPs have a fibrous nature, e.g., β‐actin, vimentin, myosin II, tublin, etc. A data set of these proteins, which we developed, contains essential chromosome proteins with classified information based on this four‐layer model and presents useful leads for further studies on chromosomal structure and function. © 2007 The Japan Chemical Journal Forum and Wiley Periodicals, Inc. Chem Rec 7: 230–237; 2007: Published online in Wiley InterScience ( www.interscience.wiley.com ) DOI 10.1002/tcr.20120" @default.
- W1991745858 created "2016-06-24" @default.
- W1991745858 creator A5024888646 @default.
- W1991745858 creator A5026448810 @default.
- W1991745858 date "2007-01-01" @default.
- W1991745858 modified "2023-10-17" @default.
- W1991745858 title "Chromosome protein framework from proteome analysis of isolated human metaphase chromosomes" @default.
- W1991745858 cites W1493549734 @default.
- W1991745858 cites W1975030887 @default.
- W1991745858 cites W1975135992 @default.
- W1991745858 cites W1980390757 @default.
- W1991745858 cites W1984357698 @default.
- W1991745858 cites W1999861460 @default.
- W1991745858 cites W2018626566 @default.
- W1991745858 cites W2025914083 @default.
- W1991745858 cites W2038972512 @default.
- W1991745858 cites W2044155153 @default.
- W1991745858 cites W2085115632 @default.
- W1991745858 cites W2087622978 @default.
- W1991745858 cites W2107259626 @default.
- W1991745858 cites W2113065553 @default.
- W1991745858 cites W2113990896 @default.
- W1991745858 cites W2126878399 @default.
- W1991745858 cites W2128443448 @default.
- W1991745858 cites W2319362197 @default.
- W1991745858 cites W2484965633 @default.
- W1991745858 doi "https://doi.org/10.1002/tcr.20120" @default.
- W1991745858 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17663445" @default.
- W1991745858 hasPublicationYear "2007" @default.
- W1991745858 type Work @default.
- W1991745858 sameAs 1991745858 @default.
- W1991745858 citedByCount "33" @default.
- W1991745858 countsByYear W19917458582012 @default.
- W1991745858 countsByYear W19917458582013 @default.
- W1991745858 countsByYear W19917458582014 @default.
- W1991745858 countsByYear W19917458582015 @default.
- W1991745858 countsByYear W19917458582016 @default.
- W1991745858 countsByYear W19917458582019 @default.
- W1991745858 countsByYear W19917458582020 @default.
- W1991745858 countsByYear W19917458582021 @default.
- W1991745858 countsByYear W19917458582023 @default.
- W1991745858 crossrefType "journal-article" @default.
- W1991745858 hasAuthorship W1991745858A5024888646 @default.
- W1991745858 hasAuthorship W1991745858A5026448810 @default.
- W1991745858 hasConcept C104317684 @default.
- W1991745858 hasConcept C104397665 @default.
- W1991745858 hasConcept C153911025 @default.
- W1991745858 hasConcept C155790170 @default.
- W1991745858 hasConcept C2778354886 @default.
- W1991745858 hasConcept C30481170 @default.
- W1991745858 hasConcept C54355233 @default.
- W1991745858 hasConcept C70278784 @default.
- W1991745858 hasConcept C86803240 @default.
- W1991745858 hasConcept C95444343 @default.
- W1991745858 hasConceptScore W1991745858C104317684 @default.
- W1991745858 hasConceptScore W1991745858C104397665 @default.
- W1991745858 hasConceptScore W1991745858C153911025 @default.
- W1991745858 hasConceptScore W1991745858C155790170 @default.
- W1991745858 hasConceptScore W1991745858C2778354886 @default.
- W1991745858 hasConceptScore W1991745858C30481170 @default.
- W1991745858 hasConceptScore W1991745858C54355233 @default.
- W1991745858 hasConceptScore W1991745858C70278784 @default.
- W1991745858 hasConceptScore W1991745858C86803240 @default.
- W1991745858 hasConceptScore W1991745858C95444343 @default.
- W1991745858 hasIssue "4" @default.
- W1991745858 hasLocation W19917458581 @default.
- W1991745858 hasLocation W19917458582 @default.
- W1991745858 hasOpenAccess W1991745858 @default.
- W1991745858 hasPrimaryLocation W19917458581 @default.
- W1991745858 hasRelatedWork W1964977825 @default.
- W1991745858 hasRelatedWork W1999938539 @default.
- W1991745858 hasRelatedWork W2125659069 @default.
- W1991745858 hasRelatedWork W2133001417 @default.
- W1991745858 hasRelatedWork W2784825908 @default.
- W1991745858 hasRelatedWork W2793314979 @default.
- W1991745858 hasRelatedWork W2799325747 @default.
- W1991745858 hasRelatedWork W2809326205 @default.
- W1991745858 hasRelatedWork W3085894733 @default.
- W1991745858 hasRelatedWork W4210532677 @default.
- W1991745858 hasVolume "7" @default.
- W1991745858 isParatext "false" @default.
- W1991745858 isRetracted "false" @default.
- W1991745858 magId "1991745858" @default.
- W1991745858 workType "article" @default.