FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1991746316> ?p ?o ?g. }

• W1991746316 endingPage "283" @default.
• W1991746316 startingPage "274" @default.
• W1991746316 abstract "Superantigens (SAg) are microbial proteins with the capacity to activate a large proportion of T cells. We have developed a novel approach for cancer immunotherapy by genetically fusing the SAg staphylococcal enterotoxin A (SEA) to a Fab-fragment of a tumor-specific antibody. Repeated exposure to SEA induces a state of unresponsiveness including cell deletion and functional hyporesponsiveness, i.e., anergy. In this study we have developed improved therapeutic schedules to allow repeated injections of Fab-SEA, limit development of immunological unresponsiveness and promote maximal anti-tumor response. Four daily injections of Fab-SEA to mice carrying B16-C215 lung metastases resulted in 90–95% reduction in the number of metastases. However, the animals did retain a minimal residual tumor disease. The immune system was in a hyporesponsive state after 4 daily Fab-SEA injections, and further injections did not improve therapy. Two repeated cycles, each comprising 4 daily injections of Fab-SEA, significantly prolonged the survival and resulted in complete cure of a fraction of the animals. A rest period of 10 days between the cycles was required to mount an efficient secondary anti-tumor response. This secondary immune response was characterized by partial recovery of cytokine production i.e., interleukin-2, interferon-γ and tumor necrosis factor-α. Strong CTL activity was detected in animals that had rested for 8 weeks between the 2 cycles. Interestingly, irrespective of the resting period, the CD4+ SEA-reactive T cells expanded in response to all 4 additional Fab-SEA injections both locally and in spleen. In contrast, only marginal expansion of CD8+ T cells was seen if restimulation was given within 1 month. Our data show that potent anti-tumor effector functions can be induced after repeated stimulation cycles with a SAg-monoclonal antibody fusion protein resulting in a CD4+ T cell-dependent cytokine release, prolonged survival and induction of complete cures. Int. J. Cancer 76:274-283, 1998.© 1998 Wiley-Liss, Inc." @default.
• W1991746316 created "2016-06-24" @default.
• W1991746316 creator A5006264745 @default.
• W1991746316 creator A5024889166 @default.
• W1991746316 creator A5028459301 @default.
• W1991746316 creator A5040895360 @default.
• W1991746316 creator A5041026517 @default.
• W1991746316 creator A5043223056 @default.
• W1991746316 date "1998-04-13" @default.
• W1991746316 modified "2023-10-15" @default.
• W1991746316 title "Repeated treatment with antibody-targeted superantigens strongly inhibits tumor growth" @default.
• W1991746316 cites W1484649728 @default.
• W1991746316 cites W1573470869 @default.
• W1991746316 cites W1591446606 @default.
• W1991746316 cites W1639400191 @default.
• W1991746316 cites W1857289711 @default.
• W1991746316 cites W1862307220 @default.
• W1991746316 cites W1922668115 @default.
• W1991746316 cites W194938466 @default.
• W1991746316 cites W1972704296 @default.
• W1991746316 cites W1974952914 @default.
• W1991746316 cites W1983037731 @default.
• W1991746316 cites W1997546745 @default.
• W1991746316 cites W2009714185 @default.
• W1991746316 cites W2016491745 @default.
• W1991746316 cites W2027306447 @default.
• W1991746316 cites W2032305786 @default.
• W1991746316 cites W2034181842 @default.
• W1991746316 cites W2036314272 @default.
• W1991746316 cites W2036368914 @default.
• W1991746316 cites W2044470666 @default.
• W1991746316 cites W2061014336 @default.
• W1991746316 cites W2064523013 @default.
• W1991746316 cites W2070878738 @default.
• W1991746316 cites W2076531990 @default.
• W1991746316 cites W2083466222 @default.
• W1991746316 cites W2086417745 @default.
• W1991746316 cites W2101771134 @default.
• W1991746316 cites W2170834275 @default.
• W1991746316 cites W2191654227 @default.
• W1991746316 cites W2230829804 @default.
• W1991746316 cites W2239968191 @default.
• W1991746316 doi "https://doi.org/10.1002/(sici)1097-0215(19980413)76:2<274::aid-ijc16>3.0.co;2-c" @default.
• W1991746316 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9537591" @default.
• W1991746316 hasPublicationYear "1998" @default.
• W1991746316 type Work @default.
• W1991746316 sameAs 1991746316 @default.
• W1991746316 citedByCount "20" @default.
• W1991746316 countsByYear W19917463162013 @default.
• W1991746316 countsByYear W19917463162014 @default.
• W1991746316 countsByYear W19917463162017 @default.
• W1991746316 crossrefType "journal-article" @default.
• W1991746316 hasAuthorship W1991746316A5006264745 @default.
• W1991746316 hasAuthorship W1991746316A5024889166 @default.
• W1991746316 hasAuthorship W1991746316A5028459301 @default.
• W1991746316 hasAuthorship W1991746316A5040895360 @default.
• W1991746316 hasAuthorship W1991746316A5041026517 @default.
• W1991746316 hasAuthorship W1991746316A5043223056 @default.
• W1991746316 hasBestOaLocation W19917463161 @default.
• W1991746316 hasConcept C159654299 @default.
• W1991746316 hasConcept C17991360 @default.
• W1991746316 hasConcept C203014093 @default.
• W1991746316 hasConcept C2776090121 @default.
• W1991746316 hasConcept C2777701055 @default.
• W1991746316 hasConcept C2778690821 @default.
• W1991746316 hasConcept C2780931953 @default.
• W1991746316 hasConcept C36333154 @default.
• W1991746316 hasConcept C71924100 @default.
• W1991746316 hasConcept C86803240 @default.
• W1991746316 hasConcept C8891405 @default.
• W1991746316 hasConceptScore W1991746316C159654299 @default.
• W1991746316 hasConceptScore W1991746316C17991360 @default.
• W1991746316 hasConceptScore W1991746316C203014093 @default.
• W1991746316 hasConceptScore W1991746316C2776090121 @default.
• W1991746316 hasConceptScore W1991746316C2777701055 @default.
• W1991746316 hasConceptScore W1991746316C2778690821 @default.
• W1991746316 hasConceptScore W1991746316C2780931953 @default.
• W1991746316 hasConceptScore W1991746316C36333154 @default.
• W1991746316 hasConceptScore W1991746316C71924100 @default.
• W1991746316 hasConceptScore W1991746316C86803240 @default.
• W1991746316 hasConceptScore W1991746316C8891405 @default.
• W1991746316 hasIssue "2" @default.
• W1991746316 hasLocation W19917463161 @default.
• W1991746316 hasLocation W19917463162 @default.
• W1991746316 hasOpenAccess W1991746316 @default.
• W1991746316 hasPrimaryLocation W19917463161 @default.
• W1991746316 hasRelatedWork W2022168473 @default.
• W1991746316 hasRelatedWork W2031687972 @default.
• W1991746316 hasRelatedWork W2082163617 @default.
• W1991746316 hasRelatedWork W2083701588 @default.
• W1991746316 hasRelatedWork W2084224278 @default.
• W1991746316 hasRelatedWork W2106141910 @default.
• W1991746316 hasRelatedWork W2121410724 @default.
• W1991746316 hasRelatedWork W4246185469 @default.
• W1991746316 hasRelatedWork W4292999066 @default.
• W1991746316 hasRelatedWork W2021372997 @default.
• W1991746316 hasVolume "76" @default.
• W1991746316 isParatext "false" @default.

• next