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• W1991749568 abstract "Although nicotinic acetylcholine receptors in both the central and peripheral nervous systems play a prominent role in the control of urinary bladder function, little is known regarding expression or function of nicotinic receptors in the bladder epithelium, or urothelium. Nicotinic receptors have been described in epithelial cells lining the upper gastrointestinal tract, respiratory tract, and the skin. Thus the present study examined the expression and functionality of nicotinic receptors in the urothelium, as well as the effects of stimulation of nicotinic receptors on the micturition reflex. mRNA for the α 3 , α 5 , α 7 , β 3 , and β 4 nicotinic subunits was identified in rat urothelial cells using RT-PCR. Western blotting also confirmed urothelial expression of the α 3 - and α 7 -subunits. Application of nicotine (50 nM) to cultured rat urothelial cells elicited an increase in intracellular Ca 2+ concentration, indicating that at least some of the subunits form functional channels. These effects were blocked by the application of the nicotinic antagonist hexamethonium. During in vivo bladder cystometrograms in urethane-anesthetized rats, intravesical administration of nicotine, choline, or the antagonists methyllycaconitine citrate and hexamethonium elicited changes in voiding parameters. Intravesical nicotine (50 nM, 1 μM) increased the intercontraction interval. Intravesical choline (1–100 μM) also affected bladder reflexes similarly, suggesting that α 7 nicotinic receptors mediate this effect. Intravesical administration of hexamethonium (1–100 μM) potentiated the nicotine-induced changes in bladder reflexes. Methyllycaconitine citrate, a specific α 7 -receptor antagonist, prevented nicotine-, choline-, and hexamethonium-induced bladder inhibition. These results are the first indication that stimulation of nonneuronal nicotinic receptors in the bladder can affect micturition." @default.
• W1991749568 created "2016-06-24" @default.
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• W1991749568 date "2006-01-01" @default.
• W1991749568 modified "2023-10-13" @default.
• W1991749568 title "Expression of functional nicotinic acetylcholine receptors in rat urinary bladder epithelial cells" @default.
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• W1991749568 doi "https://doi.org/10.1152/ajprenal.00098.2005" @default.
• W1991749568 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2760261" @default.
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