Matches in SemOpenAlex for { <https://semopenalex.org/work/W1991752641> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W1991752641 abstract "The copper containing phthalocyanine dyes, alcian blue, copper phthalocyanine tetrasulfonic acid, and Luxol fast blue MBSN are found to induce rapid calcium efflux from actively loaded sarcoplasmic reticulum (SR) vesicles. Alcian blue (5 microM), with 1 mM free Mg2+ triggered Ca2+ efflux at rates greater than 20 nmol/mg of SR/s. As in the case of Ca2+ efflux induced by calcium, heavy metals, or SH oxidation with Cu2+/cysteine, efflux induced by phthalocyanines is also stimulated by adenine containing nucleotides and inhibited by millimolar Mg2+ and submicromolar ruthenium red (RR). In addition, analogs of RR, such as hexamminecobalt(III) chloride or hexammineruthenium(III) chloride also inhibit Ca2+ efflux but are effective at somewhat higher concentrations (approximately 50 microM). Calcium release stimulated by phthalocyanines is specific for SR derived from the terminal cisternae region rather than longitudinal SR. Preincubation of alcian blue with the reducing agents, sodium dithionite, dithiothreitol, or cysteine causes complete loss of Ca2+ release activity from SR vesicles. Reoxidation of the alcian blue leads to return of the Ca2+ release activity of the phthalocyanine dye. The copper containing phthalocyanine dyes appear to cause rapid Ca2+ release from SR vesicles by oxidizing sulfhydryl groups associated with the calcium release channel. Moreover, phthalocyanines appear to act by oxidizing a pair of neighboring sulfhydryls to a disulfide because subsequent additions of the reducing agent dithiothreitol promote the closure of the Ca2+ channel and calcium re-uptake." @default.
- W1991752641 created "2016-06-24" @default.
- W1991752641 creator A5025283915 @default.
- W1991752641 creator A5033381449 @default.
- W1991752641 creator A5035001467 @default.
- W1991752641 date "1988-06-01" @default.
- W1991752641 modified "2023-09-27" @default.
- W1991752641 title "Oxidation induced by phthalocyanine dyes causes rapid calcium release from sarcoplasmic reticulum vesicles" @default.
- W1991752641 cites W113046133 @default.
- W1991752641 cites W1495748721 @default.
- W1991752641 cites W1513979592 @default.
- W1991752641 cites W1561980328 @default.
- W1991752641 cites W1563253655 @default.
- W1991752641 cites W1595204022 @default.
- W1991752641 cites W1596238171 @default.
- W1991752641 cites W1775749144 @default.
- W1991752641 cites W1909056273 @default.
- W1991752641 cites W1952906612 @default.
- W1991752641 cites W1956859188 @default.
- W1991752641 cites W1961148878 @default.
- W1991752641 cites W1969537339 @default.
- W1991752641 cites W1973150566 @default.
- W1991752641 cites W2007655540 @default.
- W1991752641 cites W2017935563 @default.
- W1991752641 cites W2020372983 @default.
- W1991752641 cites W2034046763 @default.
- W1991752641 cites W2062594397 @default.
- W1991752641 cites W2084615988 @default.
- W1991752641 cites W2087471408 @default.
- W1991752641 cites W2095152173 @default.
- W1991752641 cites W2099387884 @default.
- W1991752641 cites W2099444831 @default.
- W1991752641 cites W2112954104 @default.
- W1991752641 cites W2136304667 @default.
- W1991752641 cites W2138310843 @default.
- W1991752641 cites W2169168310 @default.
- W1991752641 doi "https://doi.org/10.1016/0003-9861(88)90633-9" @default.
- W1991752641 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2454077" @default.
- W1991752641 hasPublicationYear "1988" @default.
- W1991752641 type Work @default.
- W1991752641 sameAs 1991752641 @default.
- W1991752641 citedByCount "54" @default.
- W1991752641 countsByYear W19917526412015 @default.
- W1991752641 crossrefType "journal-article" @default.
- W1991752641 hasAuthorship W1991752641A5025283915 @default.
- W1991752641 hasAuthorship W1991752641A5033381449 @default.
- W1991752641 hasAuthorship W1991752641A5035001467 @default.
- W1991752641 hasConcept C130316041 @default.
- W1991752641 hasConcept C13965031 @default.
- W1991752641 hasConcept C178790620 @default.
- W1991752641 hasConcept C179104552 @default.
- W1991752641 hasConcept C181199279 @default.
- W1991752641 hasConcept C185592680 @default.
- W1991752641 hasConcept C2777824588 @default.
- W1991752641 hasConcept C2779201268 @default.
- W1991752641 hasConcept C2779657890 @default.
- W1991752641 hasConcept C2780761128 @default.
- W1991752641 hasConcept C41625074 @default.
- W1991752641 hasConcept C519063684 @default.
- W1991752641 hasConcept C55493867 @default.
- W1991752641 hasConceptScore W1991752641C130316041 @default.
- W1991752641 hasConceptScore W1991752641C13965031 @default.
- W1991752641 hasConceptScore W1991752641C178790620 @default.
- W1991752641 hasConceptScore W1991752641C179104552 @default.
- W1991752641 hasConceptScore W1991752641C181199279 @default.
- W1991752641 hasConceptScore W1991752641C185592680 @default.
- W1991752641 hasConceptScore W1991752641C2777824588 @default.
- W1991752641 hasConceptScore W1991752641C2779201268 @default.
- W1991752641 hasConceptScore W1991752641C2779657890 @default.
- W1991752641 hasConceptScore W1991752641C2780761128 @default.
- W1991752641 hasConceptScore W1991752641C41625074 @default.
- W1991752641 hasConceptScore W1991752641C519063684 @default.
- W1991752641 hasConceptScore W1991752641C55493867 @default.
- W1991752641 hasLocation W19917526411 @default.
- W1991752641 hasLocation W19917526412 @default.
- W1991752641 hasOpenAccess W1991752641 @default.
- W1991752641 hasPrimaryLocation W19917526411 @default.
- W1991752641 hasRelatedWork W1966357794 @default.
- W1991752641 hasRelatedWork W1977916311 @default.
- W1991752641 hasRelatedWork W1991752641 @default.
- W1991752641 hasRelatedWork W2014324393 @default.
- W1991752641 hasRelatedWork W2059509866 @default.
- W1991752641 hasRelatedWork W2086748034 @default.
- W1991752641 hasRelatedWork W2144206744 @default.
- W1991752641 hasRelatedWork W2161879274 @default.
- W1991752641 hasRelatedWork W2313997927 @default.
- W1991752641 hasRelatedWork W2316242211 @default.
- W1991752641 isParatext "false" @default.
- W1991752641 isRetracted "false" @default.
- W1991752641 magId "1991752641" @default.
- W1991752641 workType "article" @default.