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• W1991754900 abstract "Controlling the activity of a protein is necessary for defining its function in vivo. RNA aptamers are capable of inhibiting proteins with high affinity and specificity, but this effect is not readily reversible. We describe a general method for discovering aptamers that bind and inhibit their target protein, but addition of a specific small molecule disrupts the protein-RNA complex. A SELEX protocol was used to raise RNA aptamers to the DNA repair enzyme, formamidopyrimidine glycosylase (Fpg), and neomycin was employed in each round to dissociate Fpg-bound RNAs. We identified an RNA molecule able to completely inhibit Fpg at 100 nM concentration. Importantly, Fpg activity is recovered by the addition of neomycin. We envision these ligand-regulated aptamers (LIRAs) as valuable tools in the study of biological phenomena in which the timing of molecular events is critical." @default.
• W1991754900 created "2016-06-24" @default.
• W1991754900 creator A5064820122 @default.
• W1991754900 creator A5079768609 @default.
• W1991754900 date "2002-08-01" @default.
• W1991754900 modified "2023-10-17" @default.
• W1991754900 title "Controlling Protein Activity with Ligand-Regulated RNA Aptamers" @default.
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• W1991754900 doi "https://doi.org/10.1016/s1074-5521(02)00185-0" @default.
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