FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1991759548> ?p ?o ?g. }

• W1991759548 endingPage "297" @default.
• W1991759548 startingPage "292" @default.
• W1991759548 abstract "Age-related macular degeneration (AMD) is the leading cause of blindness in the world. Evidence indicates that the suppression of the ubiquitin-proteasome system (UPS) contributes to the accumulation of toxic proteins and inflammation in retinal pigment epithelium (RPE), the functional abnormalities and/or the degeneration of which are believed to be the initiators and major pathologies of AMD. To identify new protein associations with the altered UPS in AMD, we used LC-ESI-MS/MS to perform a proteomic analysis of the aqueous humor (AH) of AMD patients and matched control subjects. Six UPS-related proteins were present in the AH of the patients and control subjects. Four of the proteins, including 26S proteasome non-ATPase regulatory subunit 1 (Rpn2), were increased in patients, according to semi-quantitative proteomic profiling. An LC-MRM assay revealed a significant increase of Rpn2 in 15 AMD patients compared to the control subjects, suggesting that this protein could be a biomarker for AMD." @default.
• W1991759548 created "2016-06-24" @default.
• W1991759548 creator A5012792978 @default.
• W1991759548 creator A5032730768 @default.
• W1991759548 creator A5071756898 @default.
• W1991759548 creator A5074988696 @default.
• W1991759548 creator A5076607398 @default.
• W1991759548 creator A5079736885 @default.
• W1991759548 creator A5083290759 @default.
• W1991759548 date "2014-05-31" @default.
• W1991759548 modified "2023-10-18" @default.
• W1991759548 title "Increased 26S proteasome non-ATPase regulatory subunit 1 in the aqueous humor of patients with age-related macular degeneration" @default.
• W1991759548 cites W1597506947 @default.
• W1991759548 cites W1832030339 @default.
• W1991759548 cites W1968331373 @default.
• W1991759548 cites W1972971004 @default.
• W1991759548 cites W1976655661 @default.
• W1991759548 cites W1977532087 @default.
• W1991759548 cites W1980097678 @default.
• W1991759548 cites W1980254044 @default.
• W1991759548 cites W1982671296 @default.
• W1991759548 cites W1983887515 @default.
• W1991759548 cites W2001087765 @default.
• W1991759548 cites W2003290437 @default.
• W1991759548 cites W2008978327 @default.
• W1991759548 cites W2023642344 @default.
• W1991759548 cites W2032755197 @default.
• W1991759548 cites W2049355685 @default.
• W1991759548 cites W2081063786 @default.
• W1991759548 cites W2091973553 @default.
• W1991759548 cites W2093242012 @default.
• W1991759548 cites W2103460528 @default.
• W1991759548 cites W2121739403 @default.
• W1991759548 cites W2137280118 @default.
• W1991759548 cites W2139924841 @default.
• W1991759548 cites W2144839999 @default.
• W1991759548 cites W2152424535 @default.
• W1991759548 cites W2157313399 @default.
• W1991759548 cites W2162218055 @default.
• W1991759548 cites W2320843626 @default.
• W1991759548 doi "https://doi.org/10.5483/bmbrep.2014.47.5.193" @default.
• W1991759548 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4163863" @default.
• W1991759548 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24286321" @default.
• W1991759548 hasPublicationYear "2014" @default.
• W1991759548 type Work @default.
• W1991759548 sameAs 1991759548 @default.
• W1991759548 citedByCount "9" @default.
• W1991759548 countsByYear W19917595482014 @default.
• W1991759548 countsByYear W19917595482016 @default.
• W1991759548 countsByYear W19917595482017 @default.
• W1991759548 countsByYear W19917595482018 @default.
• W1991759548 countsByYear W19917595482022 @default.
• W1991759548 countsByYear W19917595482023 @default.
• W1991759548 crossrefType "journal-article" @default.
• W1991759548 hasAuthorship W1991759548A5012792978 @default.
• W1991759548 hasAuthorship W1991759548A5032730768 @default.
• W1991759548 hasAuthorship W1991759548A5071756898 @default.
• W1991759548 hasAuthorship W1991759548A5074988696 @default.
• W1991759548 hasAuthorship W1991759548A5076607398 @default.
• W1991759548 hasAuthorship W1991759548A5079736885 @default.
• W1991759548 hasAuthorship W1991759548A5083290759 @default.
• W1991759548 hasBestOaLocation W19917595481 @default.
• W1991759548 hasConcept C104292427 @default.
• W1991759548 hasConcept C104317684 @default.
• W1991759548 hasConcept C118487528 @default.
• W1991759548 hasConcept C25602115 @default.
• W1991759548 hasConcept C27740335 @default.
• W1991759548 hasConcept C2776403814 @default.
• W1991759548 hasConcept C2778024200 @default.
• W1991759548 hasConcept C2780827179 @default.
• W1991759548 hasConcept C2781197716 @default.
• W1991759548 hasConcept C55493867 @default.
• W1991759548 hasConcept C71924100 @default.
• W1991759548 hasConcept C86803240 @default.
• W1991759548 hasConcept C95444343 @default.
• W1991759548 hasConceptScore W1991759548C104292427 @default.
• W1991759548 hasConceptScore W1991759548C104317684 @default.
• W1991759548 hasConceptScore W1991759548C118487528 @default.
• W1991759548 hasConceptScore W1991759548C25602115 @default.
• W1991759548 hasConceptScore W1991759548C27740335 @default.
• W1991759548 hasConceptScore W1991759548C2776403814 @default.
• W1991759548 hasConceptScore W1991759548C2778024200 @default.
• W1991759548 hasConceptScore W1991759548C2780827179 @default.
• W1991759548 hasConceptScore W1991759548C2781197716 @default.
• W1991759548 hasConceptScore W1991759548C55493867 @default.
• W1991759548 hasConceptScore W1991759548C71924100 @default.
• W1991759548 hasConceptScore W1991759548C86803240 @default.
• W1991759548 hasConceptScore W1991759548C95444343 @default.
• W1991759548 hasIssue "5" @default.
• W1991759548 hasLocation W19917595481 @default.
• W1991759548 hasLocation W19917595482 @default.
• W1991759548 hasLocation W19917595483 @default.
• W1991759548 hasLocation W19917595484 @default.
• W1991759548 hasOpenAccess W1991759548 @default.
• W1991759548 hasPrimaryLocation W19917595481 @default.
• W1991759548 hasRelatedWork W1999966316 @default.
• W1991759548 hasRelatedWork W2009115348 @default.
• W1991759548 hasRelatedWork W2034839450 @default.

• next