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- W1991782565 abstract "Abstract Pancreatic islets were isolated from noninbred ob ob mice and used for evaluating how removal of extracellular Na + affects 45 Ca fluxes in the insulin-producing β cells. Isoosmotic replacement of Na + with Li + was less efficient in stimulating the incorporation of intracellular (La 3+ non-displaceable) 45 Ca than substitution with choline + or sucrose. Ample support for the significance of Na + Ca 2+ exchange for the net efflux of Ca 2+ was obtained with the observation that Na + deprivation markedly inhibited the 45 Ca washout in a Ca 2+ -deficient medium. The inhibitory action of Na + deficiency exceeded that obtained with 20 m m glucose. The 45 Ca incorporated after removal of Na + differed from that taken in response to glucose in not being exhanged with the Ca 2+ entering the β cells during glucose stimulation and in appearing also in the postmicrosomal supernatant obtained by differential centrifugation." @default.
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- W1991782565 date "1980-10-01" @default.
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- W1991782565 title "Calcium and pancreatic β-cell function XI. Modification of 45Ca fluxes by Na+ removal" @default.
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- W1991782565 doi "https://doi.org/10.1016/0006-2944(80)90005-8" @default.
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