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- W1991785251 abstract "To the Editor:I read with interest the study by Wang et al1 examining the effect of nesiritide on renal function in patients with decompensated heart failure and elevated serum creatinine concentrations. The failure of nesiritide to improve renal function in this study is both surprising and disappointing because previous studies of nesiritide have demonstrated significant natriuretic and diuretic effects, as well as diminution of the untoward effects of loop diuretics.2–4 More research is needed to fully understand the renal effects of nesiritide in patients with heart failure. In the meantime, the potential limitations of the study by Wang and associates should be taken into account to help design future studies. These limitations include the possibility that the study was underpowered to detect differences because the power calculation was based on an estimated mean initial glomerular filtration rate (GFR) of 50 mL · min−1 · 1.73 m−2 and a standard deviation (SD) of 7. The mean GFR on enrollment …" @default.
- W1991785251 created "2016-06-24" @default.
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- W1991785251 date "2005-04-12" @default.
- W1991785251 modified "2023-09-25" @default.
- W1991785251 title "Letter Regarding Article by Wang et al, “Nesiritide Does Not Improve Renal Function in Patients With Chronic Heart Failure and Worsening Serum Creatinine”" @default.
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- W1991785251 doi "https://doi.org/10.1161/01.cir.0000160855.77331.26" @default.
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