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• W1991796693 abstract "Radiotherapy is one of the main treatments for clinical cancer therapy. However, its application was limited due to lack of radiosensitivity in some cancers. Trichostatin A (TSA) is a classic histone deacetylases inhibitor (HDACi) that specifically inhibits the biochemical functions of HDAC and is demonstrated to be an active anticancer drug. However, whether it could sensitize colon cancer to radiation is not clear. Our results showed that TSA enhanced the radiosensitivity of colon cancer cells as determined by CCK-8 and clonogenic survival assay. Moreover, apoptotic cell death induced by radiation was enhanced by TSA treatment. Additionally, TSA also induced autophagic response in colon cancer cells, while autophagy inhibition led to cell apoptosis and enhanced the radiosensitivity of colon cancer cells. Our data suggested that inhibition of cytoprotective autophagy sensitizes cancer cell to radiation, which might be further investigated for clinical cancer radiotherapy." @default.
• W1991796693 created "2016-06-24" @default.
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• W1991796693 date "2013-10-13" @default.
• W1991796693 modified "2023-09-26" @default.
• W1991796693 title "Inhibition of autophagy induced by TSA sensitizes colon cancer cell to radiation" @default.
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• W1991796693 doi "https://doi.org/10.1007/s13277-013-1134-z" @default.
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• W1991796693 hasPublicationYear "2013" @default.
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