FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1991799595> ?p ?o ?g. }

• W1991799595 endingPage "147" @default.
• W1991799595 startingPage "139" @default.
• W1991799595 abstract "Genetic instability manifested as loss or gain of whole chromosomes (aneuploidy) is a newly described feature of the human brain. Aneuploidy in the brain was hypothesized to be involved in schizophrenia pathogenesis. To gain further insights into the relationship between aneuploidy in the brain and schizophrenia pathogenesis, a molecular-cytogenetic study of chromosome 1 aneuploidy was performed. Interphase multiprobe fluorescence in situ hybridization (FISH) with quantitative FISH (QFISH) and interphase chromosome-specific multicolor banding (ICS-MCB) were used to define aneuploidy rate in 12 unaffected and 12 schizophrenia brains. In the unaffected brain (n = 12; 22,794 cells analyzed), average frequencies of stochastic chromosome 1 loss and gain were 0.3% (95%CI 0.2–0.4%) and 0.3% (95%CI 0.2–0.4%), respectively. The threshold level for stochastic chromosome gain and loss (the mean + 3SD) in the normal brain was 0.7%. Average rate of aneuploidy in the schizophrenia brain (n = 12; 28,482 cells analyzed) was 0.9% (95%CI 0.3–1.5%) for chromosome 1 loss and 0.9% (95%CI 0.2–1.7%) for chromosome 1 gain. Significantly increased level of mosaic aneuploidy involving chromosome 1 was revealed in two schizophrenia brains (3.6% and 4.7% of cells with chromosome 1 loss and gain, respectively). Stochastic aneuploidy rate for chromosome 1 in the schizophrenia brain without two outliers (n = 10) reached 0.6% (95%CI 0.3–0.9%) for loss and 0.5% (0.2–0.9%) for gain and was higher than in controls (P = 0.005 and P = 0.001, respectively). Our findings support the hypothesis suggesting that subtle genomic imbalances manifesting as low-level mosaic aneuploidy may contribute to schizophrenia pathogenesis." @default.
• W1991799595 created "2016-06-24" @default.
• W1991799595 creator A5002083037 @default.
• W1991799595 creator A5003847246 @default.
• W1991799595 creator A5012868096 @default.
• W1991799595 creator A5014090990 @default.
• W1991799595 creator A5016267055 @default.
• W1991799595 creator A5032297413 @default.
• W1991799595 creator A5052681346 @default.
• W1991799595 creator A5055554212 @default.
• W1991799595 creator A5063653014 @default.
• W1991799595 creator A5082288570 @default.
• W1991799595 creator A5085052546 @default.
• W1991799595 creator A5091137751 @default.
• W1991799595 date "2008-01-01" @default.
• W1991799595 modified "2023-10-07" @default.
• W1991799595 title "The schizophrenia brain exhibits low-level aneuploidy involving chromosome 1" @default.
• W1991799595 cites W1561472109 @default.
• W1991799595 cites W1935951477 @default.
• W1991799595 cites W1975900900 @default.
• W1991799595 cites W1983367020 @default.
• W1991799595 cites W1987245301 @default.
• W1991799595 cites W2004887039 @default.
• W1991799595 cites W2011677622 @default.
• W1991799595 cites W2011816180 @default.
• W1991799595 cites W2049733177 @default.
• W1991799595 cites W2050950024 @default.
• W1991799595 cites W2051825436 @default.
• W1991799595 cites W2056985349 @default.
• W1991799595 cites W2082656717 @default.
• W1991799595 cites W2085659432 @default.
• W1991799595 cites W2087124924 @default.
• W1991799595 cites W2090854696 @default.
• W1991799595 cites W2117879536 @default.
• W1991799595 cites W2127125915 @default.
• W1991799595 cites W2128025482 @default.
• W1991799595 cites W2134984632 @default.
• W1991799595 cites W2146143136 @default.
• W1991799595 cites W2165739845 @default.
• W1991799595 cites W2166185842 @default.
• W1991799595 cites W2171446692 @default.
• W1991799595 cites W2222739502 @default.
• W1991799595 doi "https://doi.org/10.1016/j.schres.2007.07.035" @default.
• W1991799595 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17889509" @default.
• W1991799595 hasPublicationYear "2008" @default.
• W1991799595 type Work @default.
• W1991799595 sameAs 1991799595 @default.
• W1991799595 citedByCount "84" @default.
• W1991799595 countsByYear W19917995952012 @default.
• W1991799595 countsByYear W19917995952013 @default.
• W1991799595 countsByYear W19917995952014 @default.
• W1991799595 countsByYear W19917995952015 @default.
• W1991799595 countsByYear W19917995952016 @default.
• W1991799595 countsByYear W19917995952017 @default.
• W1991799595 countsByYear W19917995952018 @default.
• W1991799595 countsByYear W19917995952019 @default.
• W1991799595 countsByYear W19917995952020 @default.
• W1991799595 countsByYear W19917995952021 @default.
• W1991799595 countsByYear W19917995952022 @default.
• W1991799595 crossrefType "journal-article" @default.
• W1991799595 hasAuthorship W1991799595A5002083037 @default.
• W1991799595 hasAuthorship W1991799595A5003847246 @default.
• W1991799595 hasAuthorship W1991799595A5012868096 @default.
• W1991799595 hasAuthorship W1991799595A5014090990 @default.
• W1991799595 hasAuthorship W1991799595A5016267055 @default.
• W1991799595 hasAuthorship W1991799595A5032297413 @default.
• W1991799595 hasAuthorship W1991799595A5052681346 @default.
• W1991799595 hasAuthorship W1991799595A5055554212 @default.
• W1991799595 hasAuthorship W1991799595A5063653014 @default.
• W1991799595 hasAuthorship W1991799595A5082288570 @default.
• W1991799595 hasAuthorship W1991799595A5085052546 @default.
• W1991799595 hasAuthorship W1991799595A5091137751 @default.
• W1991799595 hasConcept C104317684 @default.
• W1991799595 hasConcept C118552586 @default.
• W1991799595 hasConcept C137555145 @default.
• W1991799595 hasConcept C140752955 @default.
• W1991799595 hasConcept C2776229224 @default.
• W1991799595 hasConcept C2776412080 @default.
• W1991799595 hasConcept C2777542201 @default.
• W1991799595 hasConcept C2779672484 @default.
• W1991799595 hasConcept C2780907584 @default.
• W1991799595 hasConcept C30481170 @default.
• W1991799595 hasConcept C54355233 @default.
• W1991799595 hasConcept C71924100 @default.
• W1991799595 hasConcept C86803240 @default.
• W1991799595 hasConceptScore W1991799595C104317684 @default.
• W1991799595 hasConceptScore W1991799595C118552586 @default.
• W1991799595 hasConceptScore W1991799595C137555145 @default.
• W1991799595 hasConceptScore W1991799595C140752955 @default.
• W1991799595 hasConceptScore W1991799595C2776229224 @default.
• W1991799595 hasConceptScore W1991799595C2776412080 @default.
• W1991799595 hasConceptScore W1991799595C2777542201 @default.
• W1991799595 hasConceptScore W1991799595C2779672484 @default.
• W1991799595 hasConceptScore W1991799595C2780907584 @default.
• W1991799595 hasConceptScore W1991799595C30481170 @default.
• W1991799595 hasConceptScore W1991799595C54355233 @default.
• W1991799595 hasConceptScore W1991799595C71924100 @default.
• W1991799595 hasConceptScore W1991799595C86803240 @default.

• next