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• W1991803053 abstract "The interaction of Cd2+ with the plasma membrane Ca2+-transporting ATPase of fish gills was studied. ATP-driven Ca2+-transport in basolateral membrane (BLM) vesicles was inhibited by Cd2+ with an I50 value of 3.0 nM at 0.25 microM free Ca2+, using EGTA, HEEDTA and NTA to buffer Ca2+ and Cd2+ concentrations. The inhibition was competitive in nature since the K0.5 value for Ca2+ increased linearly with increasing Cd2+ concentrations while the Vmax remained unchanged. The Ca2+ pump appeared to be calmodulin dependent, but we conclude that the inhibition by Cd2+ occurs directly on the Ca2+-binding site of the Ca2+-transporting ATPase and not via the Ca2+-binding sites of calmodulin. It is suggested that Cd2+-induced inhibition of Ca2+-transporting enzymes is the primary effect in the Cd2+ toxicity towards cells followed by several secondary effects due to a disturbed cellular Ca2+ metabolism. Our data illustrate that apparent stimulatory effects of low concentrations of Cd2+ on Ca2+-dependent enzymes may derive from increased free-Ca2+ levels when Cd2+ supersedes Ca2+ on the ligands." @default.
• W1991803053 created "2016-06-24" @default.
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• W1991803053 date "1988-05-01" @default.
• W1991803053 modified "2023-09-25" @default.
• W1991803053 title "Cadmium inhibits plasma membrane calcium transport" @default.
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• W1991803053 doi "https://doi.org/10.1007/bf01870448" @default.
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