FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1991822806> ?p ?o ?g. }

• W1991822806 endingPage "97" @default.
• W1991822806 startingPage "85" @default.
• W1991822806 abstract "The biosynthesis of arginine is an essential function for the metabolism of Mycobacterium tuberculosis (Mtb) and for the metabolism of many other microorganisms. The arginine repressor (ArgR) proteins control the transcription of genes encoding the arginine biosynthetic enzymes; they belong to repressors having one of the most intricate oligomerization patterns. Here, we present the crystal structure of the MtbArgR hexamer bound to three copies of the 20 base-pair DNA operator and to the co-repressor, L-arginine, determined to 3.3 A resolution. This is the first ternary structure of an intact hexameric ArgR in complex with its DNA operator. The structure reported here is very different from the suggested models of the ternary ArgR-DNA complexes; it has revealed the sophisticated symmetry of the complex and the presence of two remarkably different protomer conformations, folded and extended. Both features provide flexibility to DNA binding and are important for understanding the detailed function of ArgRs. Two of the 20 base-pair DNA operators align in a unified double-helical structure, suggesting the possible presence of a double ARG box in the promoter region of the Mtb arginine operon. Two pairs of protomers bind to the unified double ARG box so that the two folded protomers bind to the central half-sites of the double ARG box, whereas the two extended protomers bind to the remote half-sites. The protomers of the third pair bound to the single DNA operator also have a folded and an extended conformation. A probable mechanism for arginine repression is suggested on the basis of this structure." @default.
• W1991822806 created "2016-06-24" @default.
• W1991822806 creator A5034855510 @default.
• W1991822806 creator A5035963124 @default.
• W1991822806 creator A5036927633 @default.
• W1991822806 creator A5062362734 @default.
• W1991822806 date "2009-04-01" @default.
• W1991822806 modified "2023-09-27" @default.
• W1991822806 title "The Structure of the Arginine Repressor from Mycobacterium tuberculosis Bound with its DNA Operator and Co-repressor, L-Arginine" @default.
• W1991822806 cites W1508069518 @default.
• W1991822806 cites W1539796472 @default.
• W1991822806 cites W1937790690 @default.
• W1991822806 cites W1961694377 @default.
• W1991822806 cites W1965326671 @default.
• W1991822806 cites W1971922923 @default.
• W1991822806 cites W1985629904 @default.
• W1991822806 cites W1986191025 @default.
• W1991822806 cites W1994715746 @default.
• W1991822806 cites W1997093250 @default.
• W1991822806 cites W1997584637 @default.
• W1991822806 cites W1998936172 @default.
• W1991822806 cites W2014167856 @default.
• W1991822806 cites W2015546403 @default.
• W1991822806 cites W2026991541 @default.
• W1991822806 cites W2035503835 @default.
• W1991822806 cites W2039285492 @default.
• W1991822806 cites W2050843661 @default.
• W1991822806 cites W2058764769 @default.
• W1991822806 cites W2060159801 @default.
• W1991822806 cites W2062125129 @default.
• W1991822806 cites W2068599914 @default.
• W1991822806 cites W2081828865 @default.
• W1991822806 cites W2088231991 @default.
• W1991822806 cites W2097493124 @default.
• W1991822806 cites W2106882534 @default.
• W1991822806 cites W2109184569 @default.
• W1991822806 cites W2121266570 @default.
• W1991822806 cites W2128482141 @default.
• W1991822806 cites W2134575107 @default.
• W1991822806 cites W2139654449 @default.
• W1991822806 cites W2144081223 @default.
• W1991822806 cites W2159858602 @default.
• W1991822806 doi "https://doi.org/10.1016/j.jmb.2009.02.053" @default.
• W1991822806 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19265706" @default.
• W1991822806 hasPublicationYear "2009" @default.
• W1991822806 type Work @default.
• W1991822806 sameAs 1991822806 @default.
• W1991822806 citedByCount "14" @default.
• W1991822806 countsByYear W19918228062013 @default.
• W1991822806 countsByYear W19918228062014 @default.
• W1991822806 countsByYear W19918228062016 @default.
• W1991822806 countsByYear W19918228062017 @default.
• W1991822806 countsByYear W19918228062019 @default.
• W1991822806 countsByYear W19918228062020 @default.
• W1991822806 countsByYear W19918228062021 @default.
• W1991822806 countsByYear W19918228062022 @default.
• W1991822806 crossrefType "journal-article" @default.
• W1991822806 hasAuthorship W1991822806A5034855510 @default.
• W1991822806 hasAuthorship W1991822806A5035963124 @default.
• W1991822806 hasAuthorship W1991822806A5036927633 @default.
• W1991822806 hasAuthorship W1991822806A5062362734 @default.
• W1991822806 hasConcept C104317684 @default.
• W1991822806 hasConcept C107824862 @default.
• W1991822806 hasConcept C138885662 @default.
• W1991822806 hasConcept C158448853 @default.
• W1991822806 hasConcept C17020691 @default.
• W1991822806 hasConcept C179926584 @default.
• W1991822806 hasConcept C181199279 @default.
• W1991822806 hasConcept C185592680 @default.
• W1991822806 hasConcept C189754071 @default.
• W1991822806 hasConcept C203075996 @default.
• W1991822806 hasConcept C2777468819 @default.
• W1991822806 hasConcept C41895202 @default.
• W1991822806 hasConcept C515207424 @default.
• W1991822806 hasConcept C547475151 @default.
• W1991822806 hasConcept C552990157 @default.
• W1991822806 hasConcept C55493867 @default.
• W1991822806 hasConcept C71240020 @default.
• W1991822806 hasConcept C86339819 @default.
• W1991822806 hasConcept C86756495 @default.
• W1991822806 hasConcept C86803240 @default.
• W1991822806 hasConceptScore W1991822806C104317684 @default.
• W1991822806 hasConceptScore W1991822806C107824862 @default.
• W1991822806 hasConceptScore W1991822806C138885662 @default.
• W1991822806 hasConceptScore W1991822806C158448853 @default.
• W1991822806 hasConceptScore W1991822806C17020691 @default.
• W1991822806 hasConceptScore W1991822806C179926584 @default.
• W1991822806 hasConceptScore W1991822806C181199279 @default.
• W1991822806 hasConceptScore W1991822806C185592680 @default.
• W1991822806 hasConceptScore W1991822806C189754071 @default.
• W1991822806 hasConceptScore W1991822806C203075996 @default.
• W1991822806 hasConceptScore W1991822806C2777468819 @default.
• W1991822806 hasConceptScore W1991822806C41895202 @default.
• W1991822806 hasConceptScore W1991822806C515207424 @default.
• W1991822806 hasConceptScore W1991822806C547475151 @default.
• W1991822806 hasConceptScore W1991822806C552990157 @default.
• W1991822806 hasConceptScore W1991822806C55493867 @default.
• W1991822806 hasConceptScore W1991822806C71240020 @default.

• next