FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1991830982> ?p ?o ?g. }

• W1991830982 endingPage "1505" @default.
• W1991830982 startingPage "1499" @default.
• W1991830982 abstract "Abstract Activation of protein C by thrombin bound to thrombomodulin is enhanced by endothelial protein C receptor. This pathway may inhibit inflammation. We investigated effects of protein C and activated protein C on neutrophils as well as whether an endothelial protein C receptor is involved in mediating protein C effects. Neutrophils were from venous blood of healthy donors. Cell migration, respiratory burst, phagocytic activity, and apoptosis were studied by micropore filter assays and fluorometry. Receptor expression was investigated by reverse transcriptase–polymerase chain reaction (PCR) for mRNA, sodium dodecyl sulfate–polyacrylamide gel electrophoresis (SDS-PAGE) and autoradiography of immunoprecipitated receptor protein, and fluorescence-activated cell-sorter scanner (FACS) analysis using the anti–endothelial protein C receptor antibody RCR-252. Neither protein C nor activated protein C induced migration, yet both of them inhibited neutrophil chemotaxis triggered by interleukin-8, formyl-Met-Leu-Phe, antithrombin, or C5a. A protein C activation–blocking antibody against endothelial protein C receptor diminished inhibitory effects of protein C or activated protein C on migration. No effect of either protein C preparation was seen in neutrophil's respiratory burst, bacterial phagocytosis, or apoptosis assays. Endothelial protein C receptor immunoreactivity was confirmed on neutrophils by FACS. De novo synthesis is suggested by endothelial protein C receptor mRNA expression as demonstrated by reverse transcriptase PCR and immunoprecipitation SDS-PAGE analyses. Data suggest that an endothelial protein C receptor is expressed by human neutrophils whose active site ligation with either protein C or activated protein C arrests directed cell migration. Inhibitory effects of these components of the protein C pathway on neutrophil function may play a role in the protein C–based treatment of severe sepsis." @default.
• W1991830982 created "2016-06-24" @default.
• W1991830982 creator A5015360999 @default.
• W1991830982 creator A5026332836 @default.
• W1991830982 creator A5053282172 @default.
• W1991830982 creator A5056872170 @default.
• W1991830982 creator A5081956853 @default.
• W1991830982 creator A5085805107 @default.
• W1991830982 date "2003-08-15" @default.
• W1991830982 modified "2023-09-30" @default.
• W1991830982 title "Expression and function of the endothelial protein C receptor in human neutrophils" @default.
• W1991830982 cites W1508779802 @default.
• W1991830982 cites W1527823783 @default.
• W1991830982 cites W1539612689 @default.
• W1991830982 cites W1570103822 @default.
• W1991830982 cites W1589757596 @default.
• W1991830982 cites W172709144 @default.
• W1991830982 cites W1814990234 @default.
• W1991830982 cites W1897515452 @default.
• W1991830982 cites W1964415576 @default.
• W1991830982 cites W1972439920 @default.
• W1991830982 cites W1974458756 @default.
• W1991830982 cites W1979116835 @default.
• W1991830982 cites W1992696073 @default.
• W1991830982 cites W1993601122 @default.
• W1991830982 cites W2000985786 @default.
• W1991830982 cites W2005829070 @default.
• W1991830982 cites W2026106674 @default.
• W1991830982 cites W2027471559 @default.
• W1991830982 cites W2034180504 @default.
• W1991830982 cites W2042307910 @default.
• W1991830982 cites W2046913887 @default.
• W1991830982 cites W2065853122 @default.
• W1991830982 cites W2065861447 @default.
• W1991830982 cites W2073933974 @default.
• W1991830982 cites W2077392251 @default.
• W1991830982 cites W2092311768 @default.
• W1991830982 cites W2094389532 @default.
• W1991830982 cites W2106352950 @default.
• W1991830982 cites W2112348962 @default.
• W1991830982 cites W2120595618 @default.
• W1991830982 cites W2130292547 @default.
• W1991830982 cites W2140432387 @default.
• W1991830982 cites W2150145906 @default.
• W1991830982 cites W2155842931 @default.
• W1991830982 cites W2165453706 @default.
• W1991830982 cites W2170147946 @default.
• W1991830982 cites W2214759602 @default.
• W1991830982 cites W2322121630 @default.
• W1991830982 cites W314977035 @default.
• W1991830982 doi "https://doi.org/10.1182/blood-2002-12-3880" @default.
• W1991830982 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12714492" @default.
• W1991830982 hasPublicationYear "2003" @default.
• W1991830982 type Work @default.
• W1991830982 sameAs 1991830982 @default.
• W1991830982 citedByCount "173" @default.
• W1991830982 countsByYear W19918309822012 @default.
• W1991830982 countsByYear W19918309822013 @default.
• W1991830982 countsByYear W19918309822014 @default.
• W1991830982 countsByYear W19918309822015 @default.
• W1991830982 countsByYear W19918309822016 @default.
• W1991830982 countsByYear W19918309822017 @default.
• W1991830982 countsByYear W19918309822018 @default.
• W1991830982 countsByYear W19918309822019 @default.
• W1991830982 countsByYear W19918309822020 @default.
• W1991830982 countsByYear W19918309822021 @default.
• W1991830982 countsByYear W19918309822022 @default.
• W1991830982 countsByYear W19918309822023 @default.
• W1991830982 crossrefType "journal-article" @default.
• W1991830982 hasAuthorship W1991830982A5015360999 @default.
• W1991830982 hasAuthorship W1991830982A5026332836 @default.
• W1991830982 hasAuthorship W1991830982A5053282172 @default.
• W1991830982 hasAuthorship W1991830982A5056872170 @default.
• W1991830982 hasAuthorship W1991830982A5081956853 @default.
• W1991830982 hasAuthorship W1991830982A5085805107 @default.
• W1991830982 hasBestOaLocation W19918309821 @default.
• W1991830982 hasConcept C104317684 @default.
• W1991830982 hasConcept C123894998 @default.
• W1991830982 hasConcept C125268873 @default.
• W1991830982 hasConcept C153911025 @default.
• W1991830982 hasConcept C159654299 @default.
• W1991830982 hasConcept C170493617 @default.
• W1991830982 hasConcept C17971392 @default.
• W1991830982 hasConcept C201267052 @default.
• W1991830982 hasConcept C203014093 @default.
• W1991830982 hasConcept C2776816377 @default.
• W1991830982 hasConcept C2777292125 @default.
• W1991830982 hasConcept C2781287897 @default.
• W1991830982 hasConcept C40767141 @default.
• W1991830982 hasConcept C55493867 @default.
• W1991830982 hasConcept C71829478 @default.
• W1991830982 hasConcept C86803240 @default.
• W1991830982 hasConcept C88532467 @default.
• W1991830982 hasConcept C89560881 @default.
• W1991830982 hasConceptScore W1991830982C104317684 @default.
• W1991830982 hasConceptScore W1991830982C123894998 @default.
• W1991830982 hasConceptScore W1991830982C125268873 @default.
• W1991830982 hasConceptScore W1991830982C153911025 @default.

• next