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• W1991851256 abstract "This article discusses the development and use of various heavy-atom clusters (Hg4, Ir4, W11, Au11, 1.4 nm Au) that can be covalently attached to specific groups (e.g., -SH, -NH2, -COOH) on biomolecules to produce high-resolution labels visible in the electron microscope. A number of applications are given, including labeling of proteins, carbohydrates, lipids in membranes and nucleic acids. Imrpoved immunolabeling with clusters over colloidal gold probes is discussed as well as the expanded utility of some of these clusters in TEM thin sections. With silver enhancement, the 1.4 nm gold cluster provides one of the most sensitive probes known for use in EM, light and confocal microscopy and in immunblotting." @default.
• W1991851256 created "2016-06-24" @default.
• W1991851256 creator A5061530212 @default.
• W1991851256 date "1992-10-01" @default.
• W1991851256 modified "2023-09-27" @default.
• W1991851256 title "Site-specific cluster labels" @default.
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• W1991851256 doi "https://doi.org/10.1016/0304-3991(92)90010-h" @default.
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