Matches in SemOpenAlex for { <https://semopenalex.org/work/W1991878257> ?p ?o ?g. }
- W1991878257 endingPage "1447" @default.
- W1991878257 startingPage "1429" @default.
- W1991878257 abstract "Management of idiopathic glomerular disease associated with nephrotic syndrome (INS) remains controversial and one of the most complex areas relates to utilization of the drug cyclosporin. This is despite its demonstrated effectiveness in several histologic types of the INS in randomized controlled trials. Cyclosporin is effective in inducing remission of proteinuria in approximately 80% of steroid-sensitive cases of minimal change disease (MCD). Cyclosporin is also effective in both the induction of remission and long-term preservation of renal function in steroid-dependent/-resistant MCD and steroid-resistant focal segmental glomerulosclerosis (FSGS). The overall response rate in FSGS is lower than in MCD, and long-term therapy (>12 months) may be required to both achieve remission and sustain it. Cyclosporin therapy is also of benefit in reducing proteinuria in 70-80% of patients with steroid-resistant membranous nephropathy (MGN). In MGN, the maximum benefit is often delayed compared to MCD (>12 weeks). Cyclosporin is generally well tolerated and safe. The major concern remains the nephrotoxicity, but with careful monitoring of the patient's renal function; minimizing the maintenance dose and utilizing repeat renal biopsy in those receiving long-term therapy, this risk can be minimized. The algorithms have been developed derived from the best evidence in the literature in each of the histologic types to help provide a guide to the integration of cyclosporin into the management of INS for the practicing nephrologist." @default.
- W1991878257 created "2016-06-24" @default.
- W1991878257 creator A5003439019 @default.
- W1991878257 creator A5005266075 @default.
- W1991878257 creator A5006521153 @default.
- W1991878257 creator A5008206977 @default.
- W1991878257 creator A5008458050 @default.
- W1991878257 creator A5013583738 @default.
- W1991878257 creator A5042064091 @default.
- W1991878257 creator A5052017202 @default.
- W1991878257 creator A5057090299 @default.
- W1991878257 creator A5073365136 @default.
- W1991878257 creator A5081833534 @default.
- W1991878257 creator A5085246285 @default.
- W1991878257 date "2007-12-01" @default.
- W1991878257 modified "2023-10-02" @default.
- W1991878257 title "Cyclosporin in idiopathic glomerular disease associated with the nephrotic syndrome : Workshop recommendations" @default.
- W1991878257 cites W1528684376 @default.
- W1991878257 cites W1904942368 @default.
- W1991878257 cites W1940588772 @default.
- W1991878257 cites W1968481059 @default.
- W1991878257 cites W1977314871 @default.
- W1991878257 cites W1979815666 @default.
- W1991878257 cites W1981507875 @default.
- W1991878257 cites W1987931683 @default.
- W1991878257 cites W1988272035 @default.
- W1991878257 cites W1988659027 @default.
- W1991878257 cites W1994069320 @default.
- W1991878257 cites W2000001694 @default.
- W1991878257 cites W2002034691 @default.
- W1991878257 cites W2004253629 @default.
- W1991878257 cites W2005167968 @default.
- W1991878257 cites W2005989846 @default.
- W1991878257 cites W2006666860 @default.
- W1991878257 cites W2007142823 @default.
- W1991878257 cites W2007496527 @default.
- W1991878257 cites W2009826896 @default.
- W1991878257 cites W2010580624 @default.
- W1991878257 cites W2011665041 @default.
- W1991878257 cites W2013308408 @default.
- W1991878257 cites W2015702174 @default.
- W1991878257 cites W2016524458 @default.
- W1991878257 cites W2016723499 @default.
- W1991878257 cites W2017104422 @default.
- W1991878257 cites W2018726092 @default.
- W1991878257 cites W2020164466 @default.
- W1991878257 cites W2020835189 @default.
- W1991878257 cites W2021397728 @default.
- W1991878257 cites W2023720190 @default.
- W1991878257 cites W2026005197 @default.
- W1991878257 cites W2028682960 @default.
- W1991878257 cites W2028987948 @default.
- W1991878257 cites W2030397853 @default.
- W1991878257 cites W2031098987 @default.
- W1991878257 cites W2033459844 @default.
- W1991878257 cites W2035810126 @default.
- W1991878257 cites W2041318596 @default.
- W1991878257 cites W2041514348 @default.
- W1991878257 cites W2044080899 @default.
- W1991878257 cites W2044517257 @default.
- W1991878257 cites W2045668407 @default.
- W1991878257 cites W2047135575 @default.
- W1991878257 cites W2048879769 @default.
- W1991878257 cites W2051978504 @default.
- W1991878257 cites W2054225562 @default.
- W1991878257 cites W2057619478 @default.
- W1991878257 cites W2059026853 @default.
- W1991878257 cites W2059224382 @default.
- W1991878257 cites W2065234358 @default.
- W1991878257 cites W2069649947 @default.
- W1991878257 cites W2073033781 @default.
- W1991878257 cites W2076378345 @default.
- W1991878257 cites W2089913116 @default.
- W1991878257 cites W2090440028 @default.
- W1991878257 cites W2093370492 @default.
- W1991878257 cites W2103436431 @default.
- W1991878257 cites W2103788273 @default.
- W1991878257 cites W2104395416 @default.
- W1991878257 cites W2104978233 @default.
- W1991878257 cites W2108455316 @default.
- W1991878257 cites W2110230080 @default.
- W1991878257 cites W2115042832 @default.
- W1991878257 cites W2115472834 @default.
- W1991878257 cites W2122257775 @default.
- W1991878257 cites W2126226666 @default.
- W1991878257 cites W2127383350 @default.
- W1991878257 cites W2130964165 @default.
- W1991878257 cites W2132364301 @default.
- W1991878257 cites W2139917487 @default.
- W1991878257 cites W2140277420 @default.
- W1991878257 cites W2143795731 @default.
- W1991878257 cites W2151098851 @default.
- W1991878257 cites W2151438241 @default.
- W1991878257 cites W2166158692 @default.
- W1991878257 cites W2167019152 @default.
- W1991878257 cites W2169596284 @default.
- W1991878257 cites W2172139748 @default.
- W1991878257 cites W227966926 @default.