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• W1991883543 abstract "To date, no consistency exists across studies that have evaluated the relationship between hepatic lipase gene (LIPC) rs10468017 variant and advanced age-related macular degeneration (AMD).To summarize all relevant evidence for a relationship between LIPC variant and advanced AMD.The PubMed and Embase databases were searched for studies potentially eligible in any language published up to September 15, 2013.Case-control studies of 2 or more comparison groups that included patients with advanced AMD (choroidal neovascularization or geographic atrophy).Allele frequencies and genotype distributions of rs10468017 variant.Summary odds ratios (ORs) and 95% CIs were estimated under different genetic models using meta-analytic methods. A stratified analysis by advanced AMD subtypes and race/ethnicity was performed, as well as a sensitivity analysis.Data from 10 case-control studies were included in the meta-analysis. The rs10468017 variant (C→T) showed significant summary ORs of 0.81 (95% CI, 0.75-0.88), 0.83 (95% CI, 0.70-0.98), and 0.60 (95% CI, 0.44-0.81) under the allelic (T vs C), heterozygous (TC vs CC), and homozygous (TT vs CC) models, respectively. Carrying at least 1 copy of the T allele decreased the risk of choroidal neovascularization and geographic atrophy by 20% (OR, 0.80; 95% CI, 0.74-0.87) and 29% (OR, 0.71; 95% CI, 0.59-0.86), respectively. The pooled OR for white race/ethnicity under an allelic model was 0.80 (95% CI, 0.74-0.87). The sensitivity analysis indicated the robustness of our findings, and no evidence of publication bias was observed in our meta-analysis.Our meta-analysis indicates that LIPC rs10468017 variant is associated with a reduced risk of advanced AMD. This finding may lead to insights regarding the pathogenesis, prevention, and treatment of AMD." @default.
• W1991883543 created "2016-06-24" @default.
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• W1991883543 date "2014-10-01" @default.
• W1991883543 modified "2023-10-18" @default.
• W1991883543 title "The Relationship Between Hepatic Lipase Gene Variant and Advanced Age-Related Macular Degeneration" @default.
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• W1991883543 doi "https://doi.org/10.1001/jamaophthalmol.2014.1752" @default.
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