Matches in SemOpenAlex for { <https://semopenalex.org/work/W1991885178> ?p ?o ?g. }
- W1991885178 endingPage "117" @default.
- W1991885178 startingPage "117" @default.
- W1991885178 abstract "Combination of calcipotriol and methotrexate in nanostructured lipid carriers for topical delivery Yin-Ku Lin1,2, Zih-Rou Huang3, Rou-Zi Zhuo3, Jia-You Fang3,41Graduate Institute of Clinical Medical Sciences, Chang Gung University, Kweishan, Taoyuan, Taiwan; 2Department of Traditional Chinese Medicine, Chang Gung Memorial Hospital, Keelung, Taiwan; 3Pharmaceutics Laboratory, Graduate Institute of Natural Products, Chang Gung University, Kweishan, Taoyuan, Taiwan; 4Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, Saudi ArabiaAbstract: The combination of calcipotriol with methotrexate can strengthen the topical therapy for psoriasis. The aim of the present study was to evaluate the potential of nanostructured lipid carriers (NLCs) loaded with lipophilic calcipotriol and hydrophilic methotrexate as topical therapy. NLCs composed of Precirol ATO 5 with various amounts of squalene as the liquid lipid were prepared. The particle size, surface charge, molecular environment, drug permeation, and skin irritation of the carriers were assessed. Hyperproliferative skin was also used as a permeation barrier in this study. It was found that variations in the Precirol®/squalene ratio had profound effects on the physicochemical characteristics of the NLCs. The range of particle size of the NLC preparations was 270 to 320 nm, with vehicles containing a higher Precirol amount exhibiting a larger diameter. NLCs with a higher Precirol/squalene ratio also showed greater polarity in their molecular environment. Calcipotriol-loaded NLC systems provided drug fluxes of 0.62 to 1.08 μg/cm2/h, which were slightly higher or comparable to the 30% ethanol vehicle (control, 0.72 μg/cm2/h). The methotrexate amount permeating the skin was 2.4 to 4.4-times greater using NLCs compared to that with the control. Dual drugloaded NLCs exhibited reduced skin permeation of calcipotriol but not methotrexate. The in vivo topical delivery examined by confocal laser scanning microscopy (CLSM) showed a good correlation with the in vitro results. These two drugs with extremely different polarities can successfully be combined in NLCs. Results suggest that NLCs may have the potential to serve as delivery carriers for antipsoriatic drugs because of enhanced drug permeation and limited skin irritation.Keywords: psoriasis, calcipotriol, methotrexate, nanostructured lipid carriers, topical delivery" @default.
- W1991885178 created "2016-06-24" @default.
- W1991885178 creator A5025830476 @default.
- W1991885178 date "2010-02-01" @default.
- W1991885178 modified "2023-10-18" @default.
- W1991885178 title "Combination of calcipotriol and methotrexate in nanostructured lipid carriers for topical delivery" @default.
- W1991885178 cites W1579046626 @default.
- W1991885178 cites W159886350 @default.
- W1991885178 cites W1911056645 @default.
- W1991885178 cites W1964026121 @default.
- W1991885178 cites W1977107683 @default.
- W1991885178 cites W1977275550 @default.
- W1991885178 cites W1986638516 @default.
- W1991885178 cites W1990876023 @default.
- W1991885178 cites W1997206489 @default.
- W1991885178 cites W2010039501 @default.
- W1991885178 cites W2017942706 @default.
- W1991885178 cites W2026470040 @default.
- W1991885178 cites W2028761028 @default.
- W1991885178 cites W2030747032 @default.
- W1991885178 cites W2033252275 @default.
- W1991885178 cites W2034137070 @default.
- W1991885178 cites W2046017386 @default.
- W1991885178 cites W2047397273 @default.
- W1991885178 cites W2050706602 @default.
- W1991885178 cites W2054435240 @default.
- W1991885178 cites W2056764794 @default.
- W1991885178 cites W2062899886 @default.
- W1991885178 cites W2067167905 @default.
- W1991885178 cites W2074718848 @default.
- W1991885178 cites W2080090843 @default.
- W1991885178 cites W2084591341 @default.
- W1991885178 cites W2085465573 @default.
- W1991885178 cites W2086369979 @default.
- W1991885178 cites W2086652191 @default.
- W1991885178 cites W2088231584 @default.
- W1991885178 cites W2088413435 @default.
- W1991885178 cites W2092980721 @default.
- W1991885178 cites W2107048473 @default.
- W1991885178 cites W2118122517 @default.
- W1991885178 cites W2141162588 @default.
- W1991885178 cites W2144687272 @default.
- W1991885178 cites W2146408988 @default.
- W1991885178 cites W2162335472 @default.
- W1991885178 cites W2170437842 @default.
- W1991885178 cites W2323325367 @default.
- W1991885178 cites W2413791662 @default.
- W1991885178 doi "https://doi.org/10.2147/ijn.s9155" @default.
- W1991885178 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2841490" @default.
- W1991885178 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20309398" @default.
- W1991885178 hasPublicationYear "2010" @default.
- W1991885178 type Work @default.
- W1991885178 sameAs 1991885178 @default.
- W1991885178 citedByCount "40" @default.
- W1991885178 countsByYear W19918851782012 @default.
- W1991885178 countsByYear W19918851782013 @default.
- W1991885178 countsByYear W19918851782014 @default.
- W1991885178 countsByYear W19918851782015 @default.
- W1991885178 countsByYear W19918851782016 @default.
- W1991885178 countsByYear W19918851782017 @default.
- W1991885178 countsByYear W19918851782019 @default.
- W1991885178 countsByYear W19918851782020 @default.
- W1991885178 countsByYear W19918851782021 @default.
- W1991885178 countsByYear W19918851782022 @default.
- W1991885178 countsByYear W19918851782023 @default.
- W1991885178 crossrefType "journal-article" @default.
- W1991885178 hasAuthorship W1991885178A5025830476 @default.
- W1991885178 hasBestOaLocation W19918851781 @default.
- W1991885178 hasConcept C126322002 @default.
- W1991885178 hasConcept C147789679 @default.
- W1991885178 hasConcept C16005928 @default.
- W1991885178 hasConcept C185592680 @default.
- W1991885178 hasConcept C187530423 @default.
- W1991885178 hasConcept C2776009542 @default.
- W1991885178 hasConcept C2776703722 @default.
- W1991885178 hasConcept C2780564577 @default.
- W1991885178 hasConcept C2781059491 @default.
- W1991885178 hasConcept C41625074 @default.
- W1991885178 hasConcept C43617362 @default.
- W1991885178 hasConcept C50670333 @default.
- W1991885178 hasConcept C55493867 @default.
- W1991885178 hasConcept C71924100 @default.
- W1991885178 hasConcept C98274493 @default.
- W1991885178 hasConceptScore W1991885178C126322002 @default.
- W1991885178 hasConceptScore W1991885178C147789679 @default.
- W1991885178 hasConceptScore W1991885178C16005928 @default.
- W1991885178 hasConceptScore W1991885178C185592680 @default.
- W1991885178 hasConceptScore W1991885178C187530423 @default.
- W1991885178 hasConceptScore W1991885178C2776009542 @default.
- W1991885178 hasConceptScore W1991885178C2776703722 @default.
- W1991885178 hasConceptScore W1991885178C2780564577 @default.
- W1991885178 hasConceptScore W1991885178C2781059491 @default.
- W1991885178 hasConceptScore W1991885178C41625074 @default.
- W1991885178 hasConceptScore W1991885178C43617362 @default.
- W1991885178 hasConceptScore W1991885178C50670333 @default.
- W1991885178 hasConceptScore W1991885178C55493867 @default.
- W1991885178 hasConceptScore W1991885178C71924100 @default.
- W1991885178 hasConceptScore W1991885178C98274493 @default.