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• W1991888019 endingPage "7319" @default.
• W1991888019 startingPage "7307" @default.
• W1991888019 abstract "Herpes simplex virus (HSV) ICP27 is an essential and multifunctional regulator of viral gene expression that modulates RNA splicing, polyadenylation, and nuclear export. We have previously reported that ICP27 causes the cytoplasmic accumulation of unspliced alpha-globin pre-mRNA. Here we examined the effects of a series of ICP27 mutations that alter important functional regions of the protein on the processing and nuclear transport of alpha-globin and HSV ICP0 RNA. The results demonstrate that ICP27 mutants that are impaired for growth in noncomplementing cells, including mutants in the N- and C-terminal regions, are defective in the accumulation of alpha-globin pre-mRNA. Unexpectedly, several mutants that are competent to repress the expression of reporter genes in transient transfection assays failed to accumulate unspliced RNA, implying that different mechanisms are responsible for transrepression and pre-mRNA accumulation. Several mutants caused a marked increase in the length and heterogeneity of the alpha-globin mRNA poly(A) tail, suggesting that ICP27 may directly or indirectly affect the regulation of poly(A) polymerase. ICP27 was also required for the accumulation of multiple ICP0 intron-bearing transcripts, but this effect displayed a mutational sensitivity profile different from that of accumulation of unspliced alpha-globin RNA. Moreover, unlike spliced and unspliced alpha-globin RNAs, which were efficiently exported to the cytoplasm, spliced and intron-containing ICP0 transcripts were predominantly nuclear in localization, and ICP27 was not required for nuclear retention of the spliced message. We propose that these transcript- and ICP27 allele-specific differences may be explained by the presence of a strong cis-acting ICP27 response element in the alpha-globin transcript." @default.
• W1991888019 created "2016-06-24" @default.
• W1991888019 creator A5015898479 @default.
• W1991888019 creator A5041386703 @default.
• W1991888019 creator A5060792296 @default.
• W1991888019 creator A5084944682 @default.
• W1991888019 date "2000-08-15" @default.
• W1991888019 modified "2023-10-18" @default.
• W1991888019 title "Processing of α-Globin and ICP0 mRNA in Cells Infected with Herpes Simplex Virus Type 1 ICP27 Mutants" @default.
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• W1991888019 cites W1559441251 @default.
• W1991888019 cites W1577671916 @default.
• W1991888019 cites W1583466448 @default.
• W1991888019 cites W1585782442 @default.
• W1991888019 cites W1592653658 @default.
• W1991888019 cites W1611012144 @default.
• W1991888019 cites W1628312488 @default.
• W1991888019 cites W1733825645 @default.
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• W1991888019 cites W1900646268 @default.
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• W1991888019 cites W2013076780 @default.
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• W1991888019 doi "https://doi.org/10.1128/jvi.74.16.7307-7319.2000" @default.
• W1991888019 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/112251" @default.
• W1991888019 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10906184" @default.
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