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• W1991900531 abstract "ObjectivePulmonary surfactant protein (SP)-A has been implicated in the mechanisms responsible for the onset of term parturition (PNAS 2004; 101:4978). The evidence in support of this hypothesis is that: (1) intra-amniotic administration of SP-A to pregnant mice led to the onset of labor; (2) treatment with an anti-SP-A antibody prolonged gestation; and (3) the concentration of SP-A in amniotic fluid increased with advancing gestational age. This study was conducted to determine whether human term parturition is associated with changes in amniotic fluid concentration of SP-A and SP-B.Study designSP-A and SP-B concentrations were measured in amniotic fluid with a sensitive and specific immunoassay in women in the following groups: (1) mid-trimester of normal pregnancy (n = 29); (2) term pregnancy not in labor (n = 28); and (3) term pregnancy in labor (n = 26). Non-parametric statistics were used for analysis.Results(1) In the mid-trimester group, SP-A was detected in all amniotic fluid samples, whereas SP-B was detected in only 55.2% (16/29) of cases. (2) The median amniotic fluid concentrations of SP-A and SP-B were significantly higher in women at term not in labor than in those at mid-trimester (SP-A: median 5.6 μg/mL; range 2.2-15.2 μg/mL vs. median 1.64 μg/mL; range 0.1-4.7 μg/mL; and SP-B: median 0.543 μg/mL; range 0.173-1.990 μg/mL vs. median 0.0002 μg/mL; range 0.0-0.353 μg/mL; all P < .001). (3) The median amniotic fluid SP-A concentration in women at term gestation in labor was significantly lower than in those at term without labor (median 2.7μg/mL; range 1.2-10.1μg/mL vs. median 5.6 μg/mL; range 2.2-15.2 μg/mL; P < .001). (4) No significant difference was detected in amniotic fluid SP-B concentration between women at term with and without labor.ConclusionAmniotic fluid concentrations of SP-A, but not of SP-B, are decreased in women in spontaneous labor, compared to those not in labor at term. ObjectivePulmonary surfactant protein (SP)-A has been implicated in the mechanisms responsible for the onset of term parturition (PNAS 2004; 101:4978). The evidence in support of this hypothesis is that: (1) intra-amniotic administration of SP-A to pregnant mice led to the onset of labor; (2) treatment with an anti-SP-A antibody prolonged gestation; and (3) the concentration of SP-A in amniotic fluid increased with advancing gestational age. This study was conducted to determine whether human term parturition is associated with changes in amniotic fluid concentration of SP-A and SP-B. Pulmonary surfactant protein (SP)-A has been implicated in the mechanisms responsible for the onset of term parturition (PNAS 2004; 101:4978). The evidence in support of this hypothesis is that: (1) intra-amniotic administration of SP-A to pregnant mice led to the onset of labor; (2) treatment with an anti-SP-A antibody prolonged gestation; and (3) the concentration of SP-A in amniotic fluid increased with advancing gestational age. This study was conducted to determine whether human term parturition is associated with changes in amniotic fluid concentration of SP-A and SP-B. Study designSP-A and SP-B concentrations were measured in amniotic fluid with a sensitive and specific immunoassay in women in the following groups: (1) mid-trimester of normal pregnancy (n = 29); (2) term pregnancy not in labor (n = 28); and (3) term pregnancy in labor (n = 26). Non-parametric statistics were used for analysis. SP-A and SP-B concentrations were measured in amniotic fluid with a sensitive and specific immunoassay in women in the following groups: (1) mid-trimester of normal pregnancy (n = 29); (2) term pregnancy not in labor (n = 28); and (3) term pregnancy in labor (n = 26). Non-parametric statistics were used for analysis. Results(1) In the mid-trimester group, SP-A was detected in all amniotic fluid samples, whereas SP-B was detected in only 55.2% (16/29) of cases. (2) The median amniotic fluid concentrations of SP-A and SP-B were significantly higher in women at term not in labor than in those at mid-trimester (SP-A: median 5.6 μg/mL; range 2.2-15.2 μg/mL vs. median 1.64 μg/mL; range 0.1-4.7 μg/mL; and SP-B: median 0.543 μg/mL; range 0.173-1.990 μg/mL vs. median 0.0002 μg/mL; range 0.0-0.353 μg/mL; all P < .001). (3) The median amniotic fluid SP-A concentration in women at term gestation in labor was significantly lower than in those at term without labor (median 2.7μg/mL; range 1.2-10.1μg/mL vs. median 5.6 μg/mL; range 2.2-15.2 μg/mL; P < .001). (4) No significant difference was detected in amniotic fluid SP-B concentration between women at term with and without labor. (1) In the mid-trimester group, SP-A was detected in all amniotic fluid samples, whereas SP-B was detected in only 55.2% (16/29) of cases. (2) The median amniotic fluid concentrations of SP-A and SP-B were significantly higher in women at term not in labor than in those at mid-trimester (SP-A: median 5.6 μg/mL; range 2.2-15.2 μg/mL vs. median 1.64 μg/mL; range 0.1-4.7 μg/mL; and SP-B: median 0.543 μg/mL; range 0.173-1.990 μg/mL vs. median 0.0002 μg/mL; range 0.0-0.353 μg/mL; all P < .001). (3) The median amniotic fluid SP-A concentration in women at term gestation in labor was significantly lower than in those at term without labor (median 2.7μg/mL; range 1.2-10.1μg/mL vs. median 5.6 μg/mL; range 2.2-15.2 μg/mL; P < .001). (4) No significant difference was detected in amniotic fluid SP-B concentration between women at term with and without labor. ConclusionAmniotic fluid concentrations of SP-A, but not of SP-B, are decreased in women in spontaneous labor, compared to those not in labor at term. Amniotic fluid concentrations of SP-A, but not of SP-B, are decreased in women in spontaneous labor, compared to those not in labor at term." @default.
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• W1991900531 title "Spontaneous term parturition is associated with decreased amniotic fluid surfactant protein a concentration" @default.
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