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• W1991900547 abstract "Human immunodeficiency virus type 1 (HIV-1) has been found in the vitreous of persons with AIDS. Here we investigated the susceptibility of human retinal pigment epithelial (RPE) cells to HIV-1 infection in culture and the effects of HIV-1 on the phagocytic function of the RPE. We found that 10 of 11 populations of RPE cells isolated from different fetal or adult eyes were susceptible to low-level replication of HIV-1/NL4-3 as determined by the detection of viral DNA and spliced viral RNA encoding envelope. HIV-1 infection was not inhibited by recombinant soluble CD4, suggesting that CD4 is not required for virus entry into RPE cells. RPE cells fused with target cells constitutively expressing HIV-1 envelope glycoproteins, indicating that HIV-1 enters cells by receptor-mediated fusion. Exposure to HIV-1 or recombinant gp120 caused a two- to four-fold increase in the binding and uptake of isolated rod outer segments by RPE cells. These findings introduce a new cell target of HIV-1 replication in the eye and indicate that RPE cells function aberrantly when exposed to HIV-1 or its envelope glycoprotein." @default.
• W1991900547 created "2016-06-24" @default.
• W1991900547 creator A5017535422 @default.
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• W1991900547 date "2000-03-01" @default.
• W1991900547 modified "2023-09-25" @default.
• W1991900547 title "Human Immunodeficiency Virus Type 1 Can Infect Human Retinal Pigment Epithelial Cells in Culture and Alter the Ability of the Cells to Phagocytose Rod Outer Segment Membranes" @default.
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• W1991900547 doi "https://doi.org/10.1089/088922200309115" @default.
• W1991900547 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10772531" @default.
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