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- W1991906148 abstract "0.001). The majority of participants were males (83%) who had been treated with primary radiotherapy (97%) for stage I disease (53%) of the glottis (75%), and 7% had undergone total laryngectomy. Among participants, the average FACT-HN TTO: r = 0.216, P c 0.001). The FACT-HN 95% CI, 0%-11%) and 0.06/1.00 (6%; 95% CI, 0%-10%). Similar results were found for the Karnofsky performance status instrument, the DATE utility instrument, and most subscales of FACT-H&N. These “positive” and “negative” estimates of MID were statistically different (P < 0.001). DISCUSSION: Cancer survivors may be more sensitive to favorable than to unfavorable differences in wellbeing. This suggests that small improvements may be important, but decrements of similar magnitude may be below the threshold of detection for individual patients. A review of previous publications showed that “positive” MIDs were smaller than “negative” MIDs in 4 studies. CONCLUSIONS: This review suggests that across instruments and diseases, MID values remain constant at -5% to 10% of the instrument range. It may eventually be possible to estimate the MID of a new instrument by generalizing these findings, avoiding the necessity of conducting MID studies for each new instrument or patient population. ACKNOWLEDGMENT: This work was carried out as part of a Master’s thesis, and portions have been published previously." @default.
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- W1991906148 date "2002-01-01" @default.
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- W1991906148 title "Assessment of palliation in patients with lung cancer: Comparisons between patient symptom diary scores and “minimum clinical change” in quality-of-life scores" @default.
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