Matches in SemOpenAlex for { <https://semopenalex.org/work/W1991922144> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W1991922144 endingPage "1499" @default.
- W1991922144 startingPage "1495" @default.
- W1991922144 abstract "To investigate whether changes in neuronal nitric oxide synthase (nNOS) protein expression and arginase activity are implicated in impairing the neurogenic cavernosal relaxation in aged rabbits, as NO is important in the neurogenic relaxation of corpus cavernosum during the erectile state.Cavernosal specimens of young adult (3-6 months old) and aged (36-48 months old) rabbits were used for isometric tension experiments, Western blot analysis, cGMP determination and measurements of NOS and arginase activities.The neurogenic relaxation and cGMP production in response to electrical-field stimulation were significantly impaired in aged cavernosal specimens. Western blot analysis showed that nNOS protein was highly expressed in cavernosal specimens from young rabbits, but was undetectable or greatly decreased in old rabbits, with no change in overall NOS activity. Arginase activity in aged cavernosal specimens was significantly higher than in young rabbits. Supplementing with excess l-arginine, or giving S-(2-boronoethyl)-l-cysteine as an arginase inhibitor, significantly increased the neurogenic relaxation at lower frequencies only in the younger rabbits.These results suggest that impairment of neurogenic and NO-mediated relaxation in the aged corpus cavernosum possibly results from the down-regulation of nNOS protein. The reduced l-arginine bioavailability to nNOS due to accelerated arginase activity would lead to further impairment of neurogenic NO production, in concert with decreased nNOS protein expression." @default.
- W1991922144 created "2016-06-24" @default.
- W1991922144 creator A5001530671 @default.
- W1991922144 creator A5015291340 @default.
- W1991922144 creator A5029939197 @default.
- W1991922144 creator A5048350768 @default.
- W1991922144 creator A5072688075 @default.
- W1991922144 creator A5081085839 @default.
- W1991922144 date "2007-04-08" @default.
- W1991922144 modified "2023-10-16" @default.
- W1991922144 title "Roles of attenuated neuronal nitric-oxide synthase protein expression and accelerated arginase activity in impairing neurogenic relaxation of corpus cavernosum in aged rabbits" @default.
- W1991922144 cites W1957985734 @default.
- W1991922144 cites W1966924982 @default.
- W1991922144 cites W1978891369 @default.
- W1991922144 cites W1989495805 @default.
- W1991922144 cites W1991116591 @default.
- W1991922144 cites W2028971791 @default.
- W1991922144 cites W2042006175 @default.
- W1991922144 cites W2045868878 @default.
- W1991922144 cites W2059382521 @default.
- W1991922144 cites W2062855686 @default.
- W1991922144 cites W2064273870 @default.
- W1991922144 cites W2070881597 @default.
- W1991922144 cites W2085675538 @default.
- W1991922144 cites W2088831121 @default.
- W1991922144 cites W2092169332 @default.
- W1991922144 cites W2152357927 @default.
- W1991922144 cites W2164876856 @default.
- W1991922144 doi "https://doi.org/10.1111/j.1464-410x.2007.06860.x" @default.
- W1991922144 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17428245" @default.
- W1991922144 hasPublicationYear "2007" @default.
- W1991922144 type Work @default.
- W1991922144 sameAs 1991922144 @default.
- W1991922144 citedByCount "32" @default.
- W1991922144 countsByYear W19919221442012 @default.
- W1991922144 countsByYear W19919221442013 @default.
- W1991922144 countsByYear W19919221442014 @default.
- W1991922144 countsByYear W19919221442015 @default.
- W1991922144 countsByYear W19919221442016 @default.
- W1991922144 countsByYear W19919221442017 @default.
- W1991922144 countsByYear W19919221442018 @default.
- W1991922144 countsByYear W19919221442019 @default.
- W1991922144 countsByYear W19919221442020 @default.
- W1991922144 crossrefType "journal-article" @default.
- W1991922144 hasAuthorship W1991922144A5001530671 @default.
- W1991922144 hasAuthorship W1991922144A5015291340 @default.
- W1991922144 hasAuthorship W1991922144A5029939197 @default.
- W1991922144 hasAuthorship W1991922144A5048350768 @default.
- W1991922144 hasAuthorship W1991922144A5072688075 @default.
- W1991922144 hasAuthorship W1991922144A5081085839 @default.
- W1991922144 hasConcept C104317684 @default.
- W1991922144 hasConcept C126322002 @default.
- W1991922144 hasConcept C134018914 @default.
- W1991922144 hasConcept C164007495 @default.
- W1991922144 hasConcept C185592680 @default.
- W1991922144 hasConcept C2776415932 @default.
- W1991922144 hasConcept C2777468819 @default.
- W1991922144 hasConcept C2777622882 @default.
- W1991922144 hasConcept C515207424 @default.
- W1991922144 hasConcept C519581460 @default.
- W1991922144 hasConcept C55493867 @default.
- W1991922144 hasConcept C71924100 @default.
- W1991922144 hasConcept C85265743 @default.
- W1991922144 hasConceptScore W1991922144C104317684 @default.
- W1991922144 hasConceptScore W1991922144C126322002 @default.
- W1991922144 hasConceptScore W1991922144C134018914 @default.
- W1991922144 hasConceptScore W1991922144C164007495 @default.
- W1991922144 hasConceptScore W1991922144C185592680 @default.
- W1991922144 hasConceptScore W1991922144C2776415932 @default.
- W1991922144 hasConceptScore W1991922144C2777468819 @default.
- W1991922144 hasConceptScore W1991922144C2777622882 @default.
- W1991922144 hasConceptScore W1991922144C515207424 @default.
- W1991922144 hasConceptScore W1991922144C519581460 @default.
- W1991922144 hasConceptScore W1991922144C55493867 @default.
- W1991922144 hasConceptScore W1991922144C71924100 @default.
- W1991922144 hasConceptScore W1991922144C85265743 @default.
- W1991922144 hasIssue "6" @default.
- W1991922144 hasLocation W19919221441 @default.
- W1991922144 hasLocation W19919221442 @default.
- W1991922144 hasOpenAccess W1991922144 @default.
- W1991922144 hasPrimaryLocation W19919221441 @default.
- W1991922144 hasRelatedWork W1976754884 @default.
- W1991922144 hasRelatedWork W2011992952 @default.
- W1991922144 hasRelatedWork W2017976380 @default.
- W1991922144 hasRelatedWork W2062447062 @default.
- W1991922144 hasRelatedWork W2069851652 @default.
- W1991922144 hasRelatedWork W2117752645 @default.
- W1991922144 hasRelatedWork W2118602159 @default.
- W1991922144 hasRelatedWork W2170309688 @default.
- W1991922144 hasRelatedWork W2418564481 @default.
- W1991922144 hasRelatedWork W3101553925 @default.
- W1991922144 hasVolume "99" @default.
- W1991922144 isParatext "false" @default.
- W1991922144 isRetracted "false" @default.
- W1991922144 magId "1991922144" @default.
- W1991922144 workType "article" @default.