FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1991942017> ?p ?o ?g. }

• W1991942017 endingPage "449" @default.
• W1991942017 startingPage "446" @default.
• W1991942017 abstract "Interleukin-18 (IL-18)/interferon-gamma-inducing factor (IGIF) is a novel proinflammatory cytokine that can induce interferon gamma (IFN-gamma). In addition, IL-18 enhances intracellular adhesion molecule-1 (ICAM-1) expression as well as Fas ligand (FasL) expression, and induces apoptosis in hepatic injury. The aim of this study was to clarify the potential role of IL-18 in the pathogenesis of the progressive inflammation and fibrosis in biliary atresia (BA).Six children with BA before hepatic portoenterostomy (HPE), 13 with BA including 7 without jaundice and 6 with persistent jaundice after HPE, and 16 healthy controls were examined. Blood samples were obtained preoperatively from 6 patients, after HPE from 13, and after liver transplantation from 4. The IL-18 level was determined by an enzyme-linked immunosorbent assay (ELISA). Immunohistochemically, liver specimens from BA patients were studied using a monoclonal antibody to macrophage-associated antigen (CD68).IL-18 levels were elevated in the patients before HPE compared with those of the controls (349+/-54 pg/mL v. 138+/-13 pg/mL, P<.0001). After HPE, extremely high concentrations of IL-18 were observed in patients with persistent jaundice (532+/-95 pg/mL, P<.0001), and the IL-18 levels were significantly high even in the patients without jaundice (249+/-29 pg/mL, P<0.005). The high IL-18 level lasted for a long time even in the patients without jaundice after HPE. In contrast, the IL-18 levels immediately decreased after liver transplantation. Immunohistochemically, the number of CD68-positive Kupffer cells was significantly higher, and the size was larger in the livers of the patients than in the controls. The proliferation of CD68-positive cells was much more conspicuous in the liver specimens obtained during liver transplantation than in those at the time of HPE.Our findings showed elevation of serum IL-18 levels and activation of Kupffer cells in BA. IL-18 released from activated Kupffer cells might play an important role in the pathophysiology of the progressive inflammation and fibrosis in BA. Furthermore, IL-18 level may be related to the prognosis in patients with BA." @default.
• W1991942017 created "2016-06-24" @default.
• W1991942017 creator A5020593363 @default.
• W1991942017 creator A5029014038 @default.
• W1991942017 creator A5030372272 @default.
• W1991942017 creator A5031849364 @default.
• W1991942017 creator A5039413936 @default.
• W1991942017 creator A5051843684 @default.
• W1991942017 creator A5054975980 @default.
• W1991942017 creator A5074447395 @default.
• W1991942017 creator A5089030527 @default.
• W1991942017 creator A5090815270 @default.
• W1991942017 date "2000-03-01" @default.
• W1991942017 modified "2023-10-16" @default.
• W1991942017 title "Elevation of serum interleukin-18 levels and activation of kupffer cells in biliary atresia" @default.
• W1991942017 cites W1600694014 @default.
• W1991942017 cites W1716317097 @default.
• W1991942017 cites W1802860123 @default.
• W1991942017 cites W1900911764 @default.
• W1991942017 cites W1905805852 @default.
• W1991942017 cites W1942062746 @default.
• W1991942017 cites W1972941078 @default.
• W1991942017 cites W1990836208 @default.
• W1991942017 cites W1994467099 @default.
• W1991942017 cites W2000706552 @default.
• W1991942017 cites W2024239709 @default.
• W1991942017 cites W2028427669 @default.
• W1991942017 cites W2051410178 @default.
• W1991942017 cites W2058409801 @default.
• W1991942017 cites W2062346175 @default.
• W1991942017 cites W2084553857 @default.
• W1991942017 cites W2141792963 @default.
• W1991942017 cites W2171831396 @default.
• W1991942017 cites W2208015810 @default.
• W1991942017 doi "https://doi.org/10.1016/s0022-3468(00)90211-2" @default.
• W1991942017 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10726686" @default.
• W1991942017 hasPublicationYear "2000" @default.
• W1991942017 type Work @default.
• W1991942017 sameAs 1991942017 @default.
• W1991942017 citedByCount "88" @default.
• W1991942017 countsByYear W19919420172012 @default.
• W1991942017 countsByYear W19919420172013 @default.
• W1991942017 countsByYear W19919420172015 @default.
• W1991942017 countsByYear W19919420172016 @default.
• W1991942017 countsByYear W19919420172017 @default.
• W1991942017 countsByYear W19919420172018 @default.
• W1991942017 countsByYear W19919420172019 @default.
• W1991942017 countsByYear W19919420172020 @default.
• W1991942017 countsByYear W19919420172021 @default.
• W1991942017 countsByYear W19919420172022 @default.
• W1991942017 countsByYear W19919420172023 @default.
• W1991942017 crossrefType "journal-article" @default.
• W1991942017 hasAuthorship W1991942017A5020593363 @default.
• W1991942017 hasAuthorship W1991942017A5029014038 @default.
• W1991942017 hasAuthorship W1991942017A5030372272 @default.
• W1991942017 hasAuthorship W1991942017A5031849364 @default.
• W1991942017 hasAuthorship W1991942017A5039413936 @default.
• W1991942017 hasAuthorship W1991942017A5051843684 @default.
• W1991942017 hasAuthorship W1991942017A5054975980 @default.
• W1991942017 hasAuthorship W1991942017A5074447395 @default.
• W1991942017 hasAuthorship W1991942017A5089030527 @default.
• W1991942017 hasAuthorship W1991942017A5090815270 @default.
• W1991942017 hasConcept C126322002 @default.
• W1991942017 hasConcept C134018914 @default.
• W1991942017 hasConcept C142724271 @default.
• W1991942017 hasConcept C164027704 @default.
• W1991942017 hasConcept C204232928 @default.
• W1991942017 hasConcept C2776460901 @default.
• W1991942017 hasConcept C2776914184 @default.
• W1991942017 hasConcept C2778456037 @default.
• W1991942017 hasConcept C2778690821 @default.
• W1991942017 hasConcept C2779243279 @default.
• W1991942017 hasConcept C2779609443 @default.
• W1991942017 hasConcept C2911091166 @default.
• W1991942017 hasConcept C68239362 @default.
• W1991942017 hasConcept C71924100 @default.
• W1991942017 hasConcept C90924648 @default.
• W1991942017 hasConceptScore W1991942017C126322002 @default.
• W1991942017 hasConceptScore W1991942017C134018914 @default.
• W1991942017 hasConceptScore W1991942017C142724271 @default.
• W1991942017 hasConceptScore W1991942017C164027704 @default.
• W1991942017 hasConceptScore W1991942017C204232928 @default.
• W1991942017 hasConceptScore W1991942017C2776460901 @default.
• W1991942017 hasConceptScore W1991942017C2776914184 @default.
• W1991942017 hasConceptScore W1991942017C2778456037 @default.
• W1991942017 hasConceptScore W1991942017C2778690821 @default.
• W1991942017 hasConceptScore W1991942017C2779243279 @default.
• W1991942017 hasConceptScore W1991942017C2779609443 @default.
• W1991942017 hasConceptScore W1991942017C2911091166 @default.
• W1991942017 hasConceptScore W1991942017C68239362 @default.
• W1991942017 hasConceptScore W1991942017C71924100 @default.
• W1991942017 hasConceptScore W1991942017C90924648 @default.
• W1991942017 hasIssue "3" @default.
• W1991942017 hasLocation W19919420171 @default.
• W1991942017 hasLocation W19919420172 @default.
• W1991942017 hasOpenAccess W1991942017 @default.
• W1991942017 hasPrimaryLocation W19919420171 @default.
• W1991942017 hasRelatedWork W1502096631 @default.

• next