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- W1991942902 abstract "Sequential pulses of the steroid hormone ecdysone regulate the major developmental transitions in Drosophila, and the duration of each developmental stage is determined by the length of time between ecdysone pulses. Ecdysone regulates biological responses by directly initiating target gene transcription. In turn, these transcriptional responses are known to be self-limiting, with mechanisms in place to ensure regression of hormone-dependent transcription. However, the biological significance of these transcriptional repression mechanisms remains unclear. Here we show that the chromatin remodeling protein INO80 facilitates transcriptional repression of ecdysone-regulated genes during prepupal development. In ino80 mutant animals, inefficient repression of transcriptional responses to the late larval ecdysone pulse delays the onset of the subsequent prepupal ecdysone pulse, resulting in a significantly longer prepupal stage. Conversely, increased expression of ino80 is sufficient to shorten the prepupal stage by increasing the rate of transcriptional repression. Furthermore, we demonstrate that enhancing the rate of regression of the mid-prepupal competence factor βFTZ-F1 is sufficient to determine the timing of head eversion and thus the duration of prepupal development. Although ino80 is conserved from yeast to humans, this study represents the first characterization of a bona fide ino80 mutation in any metazoan, raising the possibility that the functions of ino80 in transcriptional repression and developmental timing are evolutionarily conserved." @default.
- W1991942902 created "2016-06-24" @default.
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- W1991942902 date "2014-03-01" @default.
- W1991942902 modified "2023-09-26" @default.
- W1991942902 title "INO80-dependent regression of ecdysone-induced transcriptional responses regulates developmental timing in Drosophila" @default.
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- W1991942902 doi "https://doi.org/10.1016/j.ydbio.2014.01.006" @default.
- W1991942902 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4005881" @default.
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