FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1991955057> ?p ?o ?g. }

• W1991955057 endingPage "7090" @default.
• W1991955057 startingPage "7090" @default.
• W1991955057 abstract "To assess the effect of transforming growth factor (TGF)-β inhibitor peptides (P17 and P144) on the development of laser-induced choroidal neovascularization (LI-CNV) in a rat model.Sixty-one Long-Evans rats underwent diode LI-CNV model. Forty-eight hours later, treatment was administered. The intravenous control group (IV-control) and intravenous P17 group (IV-17) received five doses (0.2 mg every 72 hours) of vehicle and P17, respectively. Four groups received intravitreal injections of P17 low-dose (LD-17; 1 mg/mL) and high-dose (HD-17; 20 mg/mL) and P144 low-dose (LD-144; 1 mg/mL) and high-dose (HD-144; 3 mg/mL), and fellow eyes received vehicle. CNV evolution was assessed weekly by fluorescein angiography (FA). After death, VEGF, TGF-β and PDGF protein levels were measured by ELISA in RPE and retina homogenates. Data were analyzed with commercially available statistical analysis software.The mean CNV area, measured in pixels, was significantly lower at the second and fourth weeks in IV-17 (P < 0.05) and from the second week in HD-17 (P < 0.05), whereas LD-144 and HD-144 showed significant differences at every time point (P < 0.05). LD-17 showed significantly lower protein levels of TGF-β in retina and PDGF in RPE (P < 0.05), whereas HD-17 showed lower levels of VEGF (RPE and retina; P < 0.05), TGF-β (RPE and retina; P < 0.05), and PDGF (RPE; P < 0.05). HD-144 showed lower VEGF levels in the retina (P < 0.05).TGF-β inhibition with these peptides represents a promising new therapeutic line for CNV targeting a different pathway than current therapies. More studies are needed to assess this effect on early CNV, alone or in combination with anti-VEGF." @default.
• W1991955057 created "2016-06-24" @default.
• W1991955057 creator A5016354085 @default.
• W1991955057 creator A5017123335 @default.
• W1991955057 creator A5018284639 @default.
• W1991955057 creator A5025999196 @default.
• W1991955057 creator A5030137276 @default.
• W1991955057 creator A5072951845 @default.
• W1991955057 creator A5087073726 @default.
• W1991955057 creator A5088533885 @default.
• W1991955057 date "2011-09-08" @default.
• W1991955057 modified "2023-10-18" @default.
• W1991955057 title "Transforming Growth Factor-β Inhibition Decreases Diode Laser–Induced Choroidal Neovascularization Development in Rats: P17 and P144 Peptides" @default.
• W1991955057 cites W1482809725 @default.
• W1991955057 cites W1508669465 @default.
• W1991955057 cites W1876006940 @default.
• W1991955057 cites W1974698710 @default.
• W1991955057 cites W1979682221 @default.
• W1991955057 cites W1983765056 @default.
• W1991955057 cites W1988981981 @default.
• W1991955057 cites W1994856689 @default.
• W1991955057 cites W2005450884 @default.
• W1991955057 cites W2012977913 @default.
• W1991955057 cites W2014990370 @default.
• W1991955057 cites W2019686619 @default.
• W1991955057 cites W2025576158 @default.
• W1991955057 cites W2029563283 @default.
• W1991955057 cites W2032768676 @default.
• W1991955057 cites W2039133374 @default.
• W1991955057 cites W2045684086 @default.
• W1991955057 cites W2049342643 @default.
• W1991955057 cites W2061673720 @default.
• W1991955057 cites W2062889513 @default.
• W1991955057 cites W2069110097 @default.
• W1991955057 cites W2069898999 @default.
• W1991955057 cites W2072838935 @default.
• W1991955057 cites W2078559905 @default.
• W1991955057 cites W2079843091 @default.
• W1991955057 cites W2080524229 @default.
• W1991955057 cites W2082887801 @default.
• W1991955057 cites W2085295554 @default.
• W1991955057 cites W2088749707 @default.
• W1991955057 cites W2100299115 @default.
• W1991955057 cites W2107751384 @default.
• W1991955057 cites W2109108576 @default.
• W1991955057 cites W2112863102 @default.
• W1991955057 cites W2113784410 @default.
• W1991955057 cites W2116261308 @default.
• W1991955057 cites W2118551928 @default.
• W1991955057 cites W2125355416 @default.
• W1991955057 cites W2151833608 @default.
• W1991955057 cites W2166241707 @default.
• W1991955057 cites W2320556745 @default.
• W1991955057 cites W2728697159 @default.
• W1991955057 doi "https://doi.org/10.1167/iovs.11-7300" @default.
• W1991955057 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21810978" @default.
• W1991955057 hasPublicationYear "2011" @default.
• W1991955057 type Work @default.
• W1991955057 sameAs 1991955057 @default.
• W1991955057 citedByCount "22" @default.
• W1991955057 countsByYear W19919550572012 @default.
• W1991955057 countsByYear W19919550572013 @default.
• W1991955057 countsByYear W19919550572014 @default.
• W1991955057 countsByYear W19919550572015 @default.
• W1991955057 countsByYear W19919550572016 @default.
• W1991955057 countsByYear W19919550572017 @default.
• W1991955057 countsByYear W19919550572018 @default.
• W1991955057 countsByYear W19919550572019 @default.
• W1991955057 countsByYear W19919550572020 @default.
• W1991955057 countsByYear W19919550572021 @default.
• W1991955057 countsByYear W19919550572022 @default.
• W1991955057 crossrefType "journal-article" @default.
• W1991955057 hasAuthorship W1991955057A5016354085 @default.
• W1991955057 hasAuthorship W1991955057A5017123335 @default.
• W1991955057 hasAuthorship W1991955057A5018284639 @default.
• W1991955057 hasAuthorship W1991955057A5025999196 @default.
• W1991955057 hasAuthorship W1991955057A5030137276 @default.
• W1991955057 hasAuthorship W1991955057A5072951845 @default.
• W1991955057 hasAuthorship W1991955057A5087073726 @default.
• W1991955057 hasAuthorship W1991955057A5088533885 @default.
• W1991955057 hasConcept C118131993 @default.
• W1991955057 hasConcept C118487528 @default.
• W1991955057 hasConcept C126322002 @default.
• W1991955057 hasConcept C134018914 @default.
• W1991955057 hasConcept C16685009 @default.
• W1991955057 hasConcept C167734588 @default.
• W1991955057 hasConcept C169760540 @default.
• W1991955057 hasConcept C170493617 @default.
• W1991955057 hasConcept C180361614 @default.
• W1991955057 hasConcept C2775960820 @default.
• W1991955057 hasConcept C2777025900 @default.
• W1991955057 hasConcept C2777093970 @default.
• W1991955057 hasConcept C2778271429 @default.
• W1991955057 hasConcept C2780248432 @default.
• W1991955057 hasConcept C2780394083 @default.
• W1991955057 hasConcept C2780827179 @default.
• W1991955057 hasConcept C2781359195 @default.
• W1991955057 hasConcept C71924100 @default.

• next