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• W1991963544 abstract "Microglial morphology and immunophenotype have been studied extensively in aging-related neurodegenerative diseases, but to a lesser extent in the normally aged CNS, and little is known about how aging affects the ability of microglia to respond to neuronal injury. The goal of the current study was to determine if aging affects the ability of microglia to divide during the early response to facial nerve axotomy. In addition, we investigated the incidence of microglial cell death during later post-axotomy time points to determine if aging had an effect on microglial turnover. We employed DNA labeling with 3H-thymidine, TUNEL and lectin histochemistry after facial nerve axotomy in young (3 months), middle-aged (15 months), and old (30 months) Fisher344-Brown Norway hybrid rats. Proliferation of microglia in old rats remained significantly higher than in young rats 4 days after injury, suggesting that regulation of microglial proliferation changes with aging. There was no aging-related difference in microglial TUNEL staining at 7, 14 or 21 days post-axotomy. Lectin histochemistry in the unoperated facial nucleus revealed aging-related morphological changes in resting microglia, including hypertrophy of the cytoplasm with dense perinuclear staining. Aging-related differences in activated microglia on the lesioned side were more subtle, although many activated microglia of aged animals continued to exhibit dense perinuclear lectin reactivity. We propose that aging-related changes in morphology in conjunction with a less regulated proliferative response in the aged facial nucleus may be a reflection of microglial senescence." @default.
• W1991963544 created "2016-06-24" @default.
• W1991963544 creator A5024029931 @default.
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• W1991963544 date "2006-10-01" @default.
• W1991963544 modified "2023-10-12" @default.
• W1991963544 title "Effect of aging on the microglial response to peripheral nerve injury" @default.
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• W1991963544 doi "https://doi.org/10.1016/j.neurobiolaging.2005.07.012" @default.
• W1991963544 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16159684" @default.
• W1991963544 hasPublicationYear "2006" @default.
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