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- W1991971087 abstract "Endometrial carcinoma is the most common gynaecological cancer in developed countries, with an annual incidence of more than 20 women in 100 000. 1 Amant F Moerman P Neven P Timmerman D Van Limbergen E Vergote I Endometrial cancer. Lancet. 2005; 366: 491-505 Summary Full Text Full Text PDF PubMed Scopus (1206) Google Scholar Postmenopausal women are predominantly affected, and the disease can have a slow natural course of progression; 70% of tumours are diagnosed at stage I when confined to the uterine corpus. Consequently, 5-year disease-specific survival is high at 80% overall. 2 Creasman WT Odicino F Maisonneuve P et al. Carcinoma of the corpus uteri: FIGO 6th annual report on the results of treatment in gynecological cancer. Int J Gynaecol Obstet. 2006; 95: S105-S143 Summary Full Text PDF PubMed Scopus (743) Google Scholar Stage I endometrial carcinoma constitutes a range of tumours with 5-year survival ranging from over 95% to less than 50%, related to histopathological risk factors. 1 Amant F Moerman P Neven P Timmerman D Van Limbergen E Vergote I Endometrial cancer. Lancet. 2005; 366: 491-505 Summary Full Text Full Text PDF PubMed Scopus (1206) Google Scholar Most patients die from distant metastases, but pelvic disease is found in 45–65% of relapsing patients who did not receive adjuvant therapy. Isolated vaginal recurrence is the dominant type of pelvic relapse. Efficacy of systematic pelvic lymphadenectomy in endometrial cancer (MRC ASTEC trial): a randomised studyOur results show no evidence of benefit in terms of overall or recurrence-free survival for pelvic lymphadenectomy in women with early endometrial cancer. Pelvic lymphadenectomy cannot be recommended as routine procedure for therapeutic purposes outside of clinical trials. Full-Text PDF Open AccessAdjuvant external beam radiotherapy in the treatment of endometrial cancer (MRC ASTEC and NCIC CTG EN.5 randomised trials): pooled trial results, systematic review, and meta-analysisAdjuvant external beam radiotherapy cannot be recommended as part of routine treatment for women with intermediate-risk or high-risk early-stage endometrial cancer with the aim of improving survival. The absolute benefit of external beam radiotherapy in preventing isolated local recurrence is small and is not without toxicity. Full-Text PDF Open Access" @default.
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- W1991971087 date "2009-01-01" @default.
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- W1991971087 title "Treatment of early endometrial carcinoma: is less more?" @default.
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- W1991971087 doi "https://doi.org/10.1016/s0140-6736(08)61768-7" @default.
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