Matches in SemOpenAlex for { <https://semopenalex.org/work/W1991978462> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W1991978462 endingPage "413" @default.
- W1991978462 startingPage "407" @default.
- W1991978462 abstract "Observational data from clinical studies indicate that the goal of first-line therapy in newly diagnosed patients with symptomatic multiple myeloma (MM) should be very good partial response (VGPR) or better, preferably before high-dose treatment. We evaluated the value of early measurements of involved free light chains (iFLC) in prediction of high-quality responses. Measuring iFLC has a potential advantage due to a short half-life compared to the half-life of the M-protein.In 36 multiple myeloma (MM) patients, we measured serial changes in iFLC and M-protein after start of treatment. iFLC and M-protein were measured before treatment, the following 5 wk days, 2, 3 and 6 wks after start of treatment.Median iFLC and M-protein half-life was 2.75 and 11.9 d, respectively. All patients with an iFLC >75 mg/L had an initial significant reduction (>20%) in iFLC, even patients with no response to treatment. The mean per cent reduction in iFLC 3 d after start of treatment was 52.3% and 23.6% (P = 0.021) in patients achieving ≥VGPR and PR, respectively. The mean per cent reduction in M-protein in patients achieving ≥VGPR and PR was not significantly different in the 6-wk study period. As a predictor of VGPR, an 80% reduction in iFLC at day 21 resulted in a sensitivity of 87.5% and a specificity of 100%.Changes in iFLC could be a tool for early identification of responders to anti-myeloma therapy. Early, sequential measurements of iFLC within the first week after start of treatment are not meaningful." @default.
- W1991978462 created "2016-06-24" @default.
- W1991978462 creator A5022411233 @default.
- W1991978462 creator A5053237556 @default.
- W1991978462 creator A5058033035 @default.
- W1991978462 creator A5060699933 @default.
- W1991978462 date "2014-06-14" @default.
- W1991978462 modified "2023-10-05" @default.
- W1991978462 title "Evaluation of the serum free light chain (sFLC) analysis in prediction of response in symptomatic multiple myeloma patients: rapid profound reduction in involved FLC predicts achievement of VGPR" @default.
- W1991978462 cites W1980881602 @default.
- W1991978462 cites W1983715506 @default.
- W1991978462 cites W2003556068 @default.
- W1991978462 cites W2008182609 @default.
- W1991978462 cites W2008384522 @default.
- W1991978462 cites W2029878538 @default.
- W1991978462 cites W2043824570 @default.
- W1991978462 cites W2044436186 @default.
- W1991978462 cites W2045603696 @default.
- W1991978462 cites W2047739508 @default.
- W1991978462 cites W2053422651 @default.
- W1991978462 cites W2053899658 @default.
- W1991978462 cites W2056955741 @default.
- W1991978462 cites W2066800926 @default.
- W1991978462 cites W2151512626 @default.
- W1991978462 cites W2155531076 @default.
- W1991978462 cites W2160088903 @default.
- W1991978462 cites W2171160798 @default.
- W1991978462 cites W4312861613 @default.
- W1991978462 doi "https://doi.org/10.1111/ejh.12376" @default.
- W1991978462 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24809596" @default.
- W1991978462 hasPublicationYear "2014" @default.
- W1991978462 type Work @default.
- W1991978462 sameAs 1991978462 @default.
- W1991978462 citedByCount "17" @default.
- W1991978462 countsByYear W19919784622014 @default.
- W1991978462 countsByYear W19919784622015 @default.
- W1991978462 countsByYear W19919784622016 @default.
- W1991978462 countsByYear W19919784622018 @default.
- W1991978462 countsByYear W19919784622020 @default.
- W1991978462 countsByYear W19919784622021 @default.
- W1991978462 countsByYear W19919784622022 @default.
- W1991978462 countsByYear W19919784622023 @default.
- W1991978462 crossrefType "journal-article" @default.
- W1991978462 hasAuthorship W1991978462A5022411233 @default.
- W1991978462 hasAuthorship W1991978462A5053237556 @default.
- W1991978462 hasAuthorship W1991978462A5058033035 @default.
- W1991978462 hasAuthorship W1991978462A5060699933 @default.
- W1991978462 hasConcept C126322002 @default.
- W1991978462 hasConcept C126894567 @default.
- W1991978462 hasConcept C141071460 @default.
- W1991978462 hasConcept C159654299 @default.
- W1991978462 hasConcept C188758523 @default.
- W1991978462 hasConcept C203014093 @default.
- W1991978462 hasConcept C2776364478 @default.
- W1991978462 hasConcept C36394416 @default.
- W1991978462 hasConcept C71924100 @default.
- W1991978462 hasConcept C90924648 @default.
- W1991978462 hasConceptScore W1991978462C126322002 @default.
- W1991978462 hasConceptScore W1991978462C126894567 @default.
- W1991978462 hasConceptScore W1991978462C141071460 @default.
- W1991978462 hasConceptScore W1991978462C159654299 @default.
- W1991978462 hasConceptScore W1991978462C188758523 @default.
- W1991978462 hasConceptScore W1991978462C203014093 @default.
- W1991978462 hasConceptScore W1991978462C2776364478 @default.
- W1991978462 hasConceptScore W1991978462C36394416 @default.
- W1991978462 hasConceptScore W1991978462C71924100 @default.
- W1991978462 hasConceptScore W1991978462C90924648 @default.
- W1991978462 hasIssue "5" @default.
- W1991978462 hasLocation W19919784621 @default.
- W1991978462 hasLocation W19919784622 @default.
- W1991978462 hasOpenAccess W1991978462 @default.
- W1991978462 hasPrimaryLocation W19919784621 @default.
- W1991978462 hasRelatedWork W12448203 @default.
- W1991978462 hasRelatedWork W1929840172 @default.
- W1991978462 hasRelatedWork W2188789993 @default.
- W1991978462 hasRelatedWork W2322488425 @default.
- W1991978462 hasRelatedWork W2359520097 @default.
- W1991978462 hasRelatedWork W2364625733 @default.
- W1991978462 hasRelatedWork W2384270049 @default.
- W1991978462 hasRelatedWork W2444061589 @default.
- W1991978462 hasRelatedWork W2467467241 @default.
- W1991978462 hasRelatedWork W3210661949 @default.
- W1991978462 hasVolume "93" @default.
- W1991978462 isParatext "false" @default.
- W1991978462 isRetracted "false" @default.
- W1991978462 magId "1991978462" @default.
- W1991978462 workType "article" @default.