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• W1991996819 abstract "The peroxisome proliferator-activated receptor (PPAR) γ is a member of the nuclear hormone receptor family, which is predominantly expressed on adipocytes and considered to be involved in the process of adipogenesis. The new thiazolidinedione (TZD) compound, T-174, developed as an antidiabetic drug, stimulated the transcription of PPARγ and the adipocyte differentiation of 3T3-L1 cells. Interestingly, T-174 induced the interaction between PPARγ and CBP (cAMP response element binding protein (CREB) binding protein), a co-factor of various transcription regulators. CBP mRNA was expressed in both preadipocytes and adipocytes. These results suggest that CBP plays a role in the PPARγ-mediated signaling pathway activated by TZD, including adipogenesis." @default.
• W1991996819 created "2016-06-24" @default.
• W1991996819 creator A5037753777 @default.
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• W1991996819 date "1997-11-01" @default.
• W1991996819 modified "2023-09-25" @default.
• W1991996819 title "The Antidiabetic Agent Thiazolidinedione Stimulates the Interaction between PPARγ and CBP" @default.
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• W1991996819 doi "https://doi.org/10.1006/bbrc.1997.7602" @default.
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