Matches in SemOpenAlex for { <https://semopenalex.org/work/W1992008173> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W1992008173 abstract "Nuclear factor of activated T cells (NFAT) plays a central role in activating gene expression at the level of chromatin structure. A study now reveals that NFAT may also help to organize chromatin domains and enable enhancer-promoter communication. In activated T cells, inducible intrachromosomal looping occurs between the tumor necrosis factor-alpha (TNF-alpha) gene promoter and two NFAT-dependent enhancers located at -9 kb and +3 kb. This topology places the TNF-alpha gene and the adjacent lymphotoxin (LT) genes in separate loops, thereby allowing independent regulation of the TNF-alpha gene within a multigene locus. These findings build on other studies that indicate that NFAT is intimately associated with activities that disrupt nucleosomes within enhancers and mobilize nucleosomes across extensive chromatin domains linking enhancers and promoters. Taken together, these studies highlight NFAT as a factor that creates a chromatin environment that is permissive for both the recruitment and the clustering of factors that control transcription at promoters and enhancers." @default.
- W1992008173 created "2016-06-24" @default.
- W1992008173 creator A5088045469 @default.
- W1992008173 date "2008-04-01" @default.
- W1992008173 modified "2023-09-26" @default.
- W1992008173 title "NFAT Is Well Placed to Direct Both Enhancer Looping and Domain-Wide Models of Enhancer Function" @default.
- W1992008173 cites W1484529414 @default.
- W1992008173 cites W1900657670 @default.
- W1992008173 cites W1969987028 @default.
- W1992008173 cites W1972823584 @default.
- W1992008173 cites W1976257926 @default.
- W1992008173 cites W1994929514 @default.
- W1992008173 cites W1995496737 @default.
- W1992008173 cites W2006463715 @default.
- W1992008173 cites W2020977773 @default.
- W1992008173 cites W2040544622 @default.
- W1992008173 cites W2064390292 @default.
- W1992008173 cites W2071984045 @default.
- W1992008173 cites W2073026107 @default.
- W1992008173 cites W2077154575 @default.
- W1992008173 cites W2083103029 @default.
- W1992008173 cites W2089894746 @default.
- W1992008173 cites W2096698736 @default.
- W1992008173 cites W2111868960 @default.
- W1992008173 cites W2124458647 @default.
- W1992008173 cites W2137625310 @default.
- W1992008173 cites W2140707292 @default.
- W1992008173 cites W2146404878 @default.
- W1992008173 cites W2146656738 @default.
- W1992008173 cites W2148379368 @default.
- W1992008173 cites W2150009446 @default.
- W1992008173 cites W2156347973 @default.
- W1992008173 cites W2157973267 @default.
- W1992008173 cites W2166760304 @default.
- W1992008173 cites W2170211828 @default.
- W1992008173 cites W2171442811 @default.
- W1992008173 doi "https://doi.org/10.1126/stke.113pe15" @default.
- W1992008173 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18385038" @default.
- W1992008173 hasPublicationYear "2008" @default.
- W1992008173 type Work @default.
- W1992008173 sameAs 1992008173 @default.
- W1992008173 citedByCount "13" @default.
- W1992008173 countsByYear W19920081732012 @default.
- W1992008173 countsByYear W19920081732014 @default.
- W1992008173 countsByYear W19920081732015 @default.
- W1992008173 countsByYear W19920081732017 @default.
- W1992008173 crossrefType "journal-article" @default.
- W1992008173 hasAuthorship W1992008173A5088045469 @default.
- W1992008173 hasConcept C101762097 @default.
- W1992008173 hasConcept C104317684 @default.
- W1992008173 hasConcept C111936080 @default.
- W1992008173 hasConcept C150194340 @default.
- W1992008173 hasConcept C165864922 @default.
- W1992008173 hasConcept C189938988 @default.
- W1992008173 hasConcept C21784809 @default.
- W1992008173 hasConcept C39981086 @default.
- W1992008173 hasConcept C54355233 @default.
- W1992008173 hasConcept C83640560 @default.
- W1992008173 hasConcept C84772758 @default.
- W1992008173 hasConcept C86339819 @default.
- W1992008173 hasConcept C86803240 @default.
- W1992008173 hasConcept C95444343 @default.
- W1992008173 hasConceptScore W1992008173C101762097 @default.
- W1992008173 hasConceptScore W1992008173C104317684 @default.
- W1992008173 hasConceptScore W1992008173C111936080 @default.
- W1992008173 hasConceptScore W1992008173C150194340 @default.
- W1992008173 hasConceptScore W1992008173C165864922 @default.
- W1992008173 hasConceptScore W1992008173C189938988 @default.
- W1992008173 hasConceptScore W1992008173C21784809 @default.
- W1992008173 hasConceptScore W1992008173C39981086 @default.
- W1992008173 hasConceptScore W1992008173C54355233 @default.
- W1992008173 hasConceptScore W1992008173C83640560 @default.
- W1992008173 hasConceptScore W1992008173C84772758 @default.
- W1992008173 hasConceptScore W1992008173C86339819 @default.
- W1992008173 hasConceptScore W1992008173C86803240 @default.
- W1992008173 hasConceptScore W1992008173C95444343 @default.
- W1992008173 hasIssue "13" @default.
- W1992008173 hasLocation W19920081731 @default.
- W1992008173 hasLocation W19920081732 @default.
- W1992008173 hasOpenAccess W1992008173 @default.
- W1992008173 hasPrimaryLocation W19920081731 @default.
- W1992008173 hasRelatedWork W1992008173 @default.
- W1992008173 hasRelatedWork W2010369135 @default.
- W1992008173 hasRelatedWork W2061275528 @default.
- W1992008173 hasRelatedWork W2146656738 @default.
- W1992008173 hasRelatedWork W2154077612 @default.
- W1992008173 hasRelatedWork W2967307326 @default.
- W1992008173 hasRelatedWork W2989914470 @default.
- W1992008173 hasRelatedWork W3014694882 @default.
- W1992008173 hasRelatedWork W3018619245 @default.
- W1992008173 hasRelatedWork W4224249716 @default.
- W1992008173 hasVolume "1" @default.
- W1992008173 isParatext "false" @default.
- W1992008173 isRetracted "false" @default.
- W1992008173 magId "1992008173" @default.
- W1992008173 workType "article" @default.