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- W1992008474 abstract "Pancreatic beta-cell function is essential for the regulation of glucose homeostasis in humans, and its impairment leads to the development of type 2 diabetes. Inputs from glucose and cell surface receptors act together to initiate the beta-cell stimulus-response coupling that ultimately leads to the release of insulin. Phosphorylated inositol compounds have recently emerged as key players at all levels of the stimulus-secretion coupling process. In this current review, we seek to highlight recent advances in beta-cell phosphoinositide research by dividing our examination into two sections. The first involves the events that lead to insulin secretion. This includes both new roles for inositol polyphosphates, particularly inositol hexakisphosphate, and both conventional and 3-phosphorylated inositol lipids. In the second section, we deal with the more novel concept of the autocrine role of insulin. Here, released insulin initiates signal transduction cascades, principally through the activity of phosphatidylinositol 3-kinase. This new round of signal transduction has been established to activate key beta-cell genes, particularly the insulin gene itself. More controversially, this insulin feedback has also been suggested to either terminate or enhance insulin secretion events." @default.
- W1992008474 created "2016-06-24" @default.
- W1992008474 creator A5033200110 @default.
- W1992008474 creator A5037533958 @default.
- W1992008474 creator A5064964707 @default.
- W1992008474 creator A5074543896 @default.
- W1992008474 date "2002-12-01" @default.
- W1992008474 modified "2023-10-04" @default.
- W1992008474 title "Phosphorylated inositol compounds in β-cell stimulus-response coupling" @default.
- W1992008474 cites W1493113589 @default.
- W1992008474 cites W1495556880 @default.
- W1992008474 cites W1549576466 @default.
- W1992008474 cites W1553844088 @default.
- W1992008474 cites W1554519792 @default.
- W1992008474 cites W1570052704 @default.
- W1992008474 cites W1580644393 @default.
- W1992008474 cites W1672965892 @default.
- W1992008474 cites W1688381890 @default.
- W1992008474 cites W1697523131 @default.
- W1992008474 cites W1797502167 @default.
- W1992008474 cites W1866620858 @default.
- W1992008474 cites W1927629618 @default.
- W1992008474 cites W1965209959 @default.
- W1992008474 cites W1967086988 @default.
- W1992008474 cites W1971547187 @default.
- W1992008474 cites W1973643499 @default.
- W1992008474 cites W1973982033 @default.
- W1992008474 cites W1979770710 @default.
- W1992008474 cites W1979965517 @default.
- W1992008474 cites W1981747327 @default.
- W1992008474 cites W1985149672 @default.
- W1992008474 cites W1989246214 @default.
- W1992008474 cites W1992002046 @default.
- W1992008474 cites W1992968276 @default.
- W1992008474 cites W1995707166 @default.
- W1992008474 cites W1997093700 @default.
- W1992008474 cites W2002127663 @default.
- W1992008474 cites W2005975977 @default.
- W1992008474 cites W2008815341 @default.
- W1992008474 cites W2011506953 @default.
- W1992008474 cites W2012301429 @default.
- W1992008474 cites W2015044058 @default.
- W1992008474 cites W2019275035 @default.
- W1992008474 cites W2019926410 @default.
- W1992008474 cites W2022092956 @default.
- W1992008474 cites W2022517367 @default.
- W1992008474 cites W2026509244 @default.
- W1992008474 cites W2028136399 @default.
- W1992008474 cites W2036006235 @default.
- W1992008474 cites W2038104864 @default.
- W1992008474 cites W2040692229 @default.
- W1992008474 cites W2042381753 @default.
- W1992008474 cites W2044927096 @default.
- W1992008474 cites W2050240434 @default.
- W1992008474 cites W2054746739 @default.
- W1992008474 cites W2055410445 @default.
- W1992008474 cites W2059604987 @default.
- W1992008474 cites W2062996401 @default.
- W1992008474 cites W2064365050 @default.
- W1992008474 cites W2064393764 @default.
- W1992008474 cites W2068762378 @default.
- W1992008474 cites W2071786252 @default.
- W1992008474 cites W2076964520 @default.
- W1992008474 cites W2077178297 @default.
- W1992008474 cites W2077417063 @default.
- W1992008474 cites W2080315484 @default.
- W1992008474 cites W2080419891 @default.
- W1992008474 cites W2082648108 @default.
- W1992008474 cites W2085693261 @default.
- W1992008474 cites W2085697729 @default.
- W1992008474 cites W2086192954 @default.
- W1992008474 cites W2091389339 @default.
- W1992008474 cites W2091444057 @default.
- W1992008474 cites W2092162739 @default.
- W1992008474 cites W2101433657 @default.
- W1992008474 cites W2101826414 @default.
- W1992008474 cites W2102980586 @default.
- W1992008474 cites W2104064337 @default.
- W1992008474 cites W2104395802 @default.
- W1992008474 cites W2104433712 @default.
- W1992008474 cites W2104768673 @default.
- W1992008474 cites W2104776146 @default.
- W1992008474 cites W2107692569 @default.
- W1992008474 cites W2112043438 @default.
- W1992008474 cites W2112581459 @default.
- W1992008474 cites W2123156022 @default.
- W1992008474 cites W2125285674 @default.
- W1992008474 cites W2126229699 @default.
- W1992008474 cites W2127109293 @default.
- W1992008474 cites W2146718650 @default.
- W1992008474 cites W2151570019 @default.
- W1992008474 cites W2153742172 @default.
- W1992008474 cites W2159584067 @default.
- W1992008474 cites W2161641259 @default.
- W1992008474 cites W2172039316 @default.
- W1992008474 cites W2239442732 @default.
- W1992008474 cites W2287333882 @default.
- W1992008474 cites W2314701087 @default.