FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1992009093> ?p ?o ?g. }

• W1992009093 endingPage "145" @default.
• W1992009093 startingPage "138" @default.
• W1992009093 abstract "Orexins A and B are a pair of neuropeptides implicated in the regulation of feeding and arousal behavior mediated through two orexin receptors type 1 and type 2. We have determined the arousal effects of newly developed selective orexin receptor type 2 agonist, [Ala11]orexin-B, on the sleep-wake cycle in rats. The effects of third ventricle intracerebroventricular (ICV) infusion of the novel orexin receptor type 2 selective agonist, [Ala11]orexin-B, on the sleep-wake cycle were investigated. ICV infusion of [Ala11]orexin-B (1, 10 and 40 nmol) during the light period (11:00-16:00) dose-dependently resulted in a significant increase in wake duration by 46.9% (n = 5, P < 0.05), 159.2% (n = 4, P < 0.01) and 163.6% (n = 7, P < 0.01)), respectively, and a significant decrease in rapid eye movement (REM) (P < 0.01) and non-REM sleep (P < 0.01) for all doses. In contrast, ICV infusion of orexin B at the same doses (1, 10 and 40 nmol) caused a 16.6% (n = 6, non-significant), 99.8% (n = 6, P < 0.05) and 72.0% (n = 4, P < 0.05) increase in wakefulness, respectively. Moreover, orexin-A, which exerts its effects through orexin receptor type 1 and orexin receptor type 2 with similar potency, resulted in a significant increase in wakefulness duration by 17.1% (n = 6, P < 0.05), 184.0% (n = 6, P < 0.01) and 228.6% (n = 6, P < 0.01) at doses of 0.1, 1 and 10 nmol, respectively. Further, the enhancement of wakefulness was accompanied by a marked reduction in REM and non-REM sleep. These findings suggest that orexin receptor type 2 plays an important role in the modulation of sleep-wake state and behavioral responses." @default.
• W1992009093 created "2016-06-24" @default.
• W1992009093 creator A5044498054 @default.
• W1992009093 creator A5074366590 @default.
• W1992009093 date "2005-06-01" @default.
• W1992009093 modified "2023-09-27" @default.
• W1992009093 title "Selective stimulation of orexin receptor type 2 promotes wakefulness in freely behaving rats" @default.
• W1992009093 cites W1519232679 @default.
• W1992009093 cites W1627229807 @default.
• W1992009093 cites W1896505318 @default.
• W1992009093 cites W1942962897 @default.
• W1992009093 cites W1945000294 @default.
• W1992009093 cites W1963609767 @default.
• W1992009093 cites W1977320288 @default.
• W1992009093 cites W1983298714 @default.
• W1992009093 cites W1989776859 @default.
• W1992009093 cites W1994915333 @default.
• W1992009093 cites W1998101177 @default.
• W1992009093 cites W1999331745 @default.
• W1992009093 cites W2000784291 @default.
• W1992009093 cites W2013655437 @default.
• W1992009093 cites W2024348439 @default.
• W1992009093 cites W2027740042 @default.
• W1992009093 cites W2031462960 @default.
• W1992009093 cites W2035053157 @default.
• W1992009093 cites W2035662131 @default.
• W1992009093 cites W2041511326 @default.
• W1992009093 cites W2041731336 @default.
• W1992009093 cites W2049088920 @default.
• W1992009093 cites W2061552936 @default.
• W1992009093 cites W2071189170 @default.
• W1992009093 cites W2072154498 @default.
• W1992009093 cites W2074270135 @default.
• W1992009093 cites W2077244173 @default.
• W1992009093 cites W2082265821 @default.
• W1992009093 cites W2084969235 @default.
• W1992009093 cites W2093069882 @default.
• W1992009093 cites W2093349190 @default.
• W1992009093 cites W2117454601 @default.
• W1992009093 cites W2118145284 @default.
• W1992009093 cites W2120543763 @default.
• W1992009093 cites W2150132984 @default.
• W1992009093 cites W2152211310 @default.
• W1992009093 cites W2159953069 @default.
• W1992009093 cites W2167382671 @default.
• W1992009093 cites W2169378022 @default.
• W1992009093 cites W2317902632 @default.
• W1992009093 cites W26111232 @default.
• W1992009093 doi "https://doi.org/10.1016/j.brainres.2005.04.064" @default.
• W1992009093 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15919057" @default.
• W1992009093 hasPublicationYear "2005" @default.
• W1992009093 type Work @default.
• W1992009093 sameAs 1992009093 @default.
• W1992009093 citedByCount "69" @default.
• W1992009093 countsByYear W19920090932012 @default.
• W1992009093 countsByYear W19920090932013 @default.
• W1992009093 countsByYear W19920090932014 @default.
• W1992009093 countsByYear W19920090932015 @default.
• W1992009093 countsByYear W19920090932016 @default.
• W1992009093 countsByYear W19920090932017 @default.
• W1992009093 countsByYear W19920090932018 @default.
• W1992009093 countsByYear W19920090932019 @default.
• W1992009093 countsByYear W19920090932020 @default.
• W1992009093 countsByYear W19920090932021 @default.
• W1992009093 countsByYear W19920090932022 @default.
• W1992009093 countsByYear W19920090932023 @default.
• W1992009093 crossrefType "journal-article" @default.
• W1992009093 hasAuthorship W1992009093A5044498054 @default.
• W1992009093 hasAuthorship W1992009093A5074366590 @default.
• W1992009093 hasConcept C118303440 @default.
• W1992009093 hasConcept C118552586 @default.
• W1992009093 hasConcept C126322002 @default.
• W1992009093 hasConcept C134018914 @default.
• W1992009093 hasConcept C170493617 @default.
• W1992009093 hasConcept C185592680 @default.
• W1992009093 hasConcept C24998067 @default.
• W1992009093 hasConcept C2776119998 @default.
• W1992009093 hasConcept C2778938600 @default.
• W1992009093 hasConcept C2779320081 @default.
• W1992009093 hasConcept C2779605129 @default.
• W1992009093 hasConcept C2779680196 @default.
• W1992009093 hasConcept C2780714764 @default.
• W1992009093 hasConcept C522805319 @default.
• W1992009093 hasConcept C71924100 @default.
• W1992009093 hasConceptScore W1992009093C118303440 @default.
• W1992009093 hasConceptScore W1992009093C118552586 @default.
• W1992009093 hasConceptScore W1992009093C126322002 @default.
• W1992009093 hasConceptScore W1992009093C134018914 @default.
• W1992009093 hasConceptScore W1992009093C170493617 @default.
• W1992009093 hasConceptScore W1992009093C185592680 @default.
• W1992009093 hasConceptScore W1992009093C24998067 @default.
• W1992009093 hasConceptScore W1992009093C2776119998 @default.
• W1992009093 hasConceptScore W1992009093C2778938600 @default.
• W1992009093 hasConceptScore W1992009093C2779320081 @default.
• W1992009093 hasConceptScore W1992009093C2779605129 @default.
• W1992009093 hasConceptScore W1992009093C2779680196 @default.
• W1992009093 hasConceptScore W1992009093C2780714764 @default.
• W1992009093 hasConceptScore W1992009093C522805319 @default.

• next