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• W1992012091 abstract "Nearly 1 billion people around the world are obese and this number is ever increasing [ [1] Flegal K.M. Carroll M.D. Kit B.K. Ogden C.L. Prevalence of overweight and trends in the distribution of body mass index among US adults. 1999–2010. JAMA. 2012; ([Epub ahead of print]) Google Scholar ]. Obesity ranks among the most pressing issues of our times, akin to syphilis and clean water and represents imbalances in energy metabolism and an overall excess storage of nutrients. In our increasingly complex world, obesity, metabolic syndrome, anxiety and depression are intertwined with stressors including lack of sleep, fetal malnutrition and socio-economic inequities [ 2 Knutson K.L. Van Cauter E. Associations between sleep loss and increased risk of obesity and diabetes. Ann N Y Acad Sci. 2008; 1129: 287-304 Crossref PubMed Scopus (552) Google Scholar , 3 Morrison J.L. Duffield J.A. Muhlhausler B.S. Gentilli S. McMillen I.C. Fetal growth restriction, catch up growth and the early origins of insulin resistance and visceral obesity. Pediatr Nephrol. 2010; 25: 669-677 Crossref PubMed Scopus (137) Google Scholar ]. Allostasis is the adaptation to acute stress involving integrated responses of the nervous and endocrine systems which restore homeostasis. The “allostatic load” is the prolonged activation of these systems, including the HPA axis and output of stress hormones, to adapt to chronic stress; this may change the nervous and endocrine systems and includes obesity, metabolic syndrome and type 2 diabetes [ 4 McEwen B.S. Protective and damaging effects of stress mediators. New Engl J Med. 1998; 338: 171-179 Crossref PubMed Scopus (4646) Google Scholar , 5 Danese A. McEwen B.S. Adverse childhood experiences, allostasis, allostatic load, and age-related disease. Physiol Behav. 2011; ([Epub ahead of print]) PubMed Google Scholar ]. To better understand the pathophysiological mechanisms that underlie obesity, increasing attention is being paid to central regulatory element in energy homeostasis, including food intake and energy expenditure. The corticotropin releasing factor (CRF) system interacting with other neuro-peptides is directly implicated in the regulation of energy balance and may participate in the pathophysiology of obesity [ [6] Arase K. York D.A. Shimizu H. Shargill N. Bray G.A. Effects of corticotropin-releasing factor on food intake and brown adipose tissue thermogenesis in rats. Am J Physiol. 1988; 255: E255-E259 PubMed Google Scholar ]. Alterations in the interaction of the CRF system with other neuro-peptides, modified in part by external stimuli such as stress, lead to alteration of the neuro-hormonal system and abnormal eating behaviors." @default.
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• W1992012091 title "Corticotropin releasing factor (CRF) and obesity" @default.
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• W1992012091 doi "https://doi.org/10.1016/j.maturitas.2012.01.015" @default.
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