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• W1992012100 abstract "<b><i>Objective: </i></b>Recent case reports suggest a link between reduced melanocortinergic tone and both obesity and attention deficit / hyperactivity disorder (ADHD). We present the case of a 13-year-old, male, obese <i>MC4R</i> mutation carrier with ADHD. <b><i>Case Report: </i></b>The boy carries a heterozygous mutation in the <i>melanocortin 4 receptor</i> gene (<i>MC4R; </i>Met281Val), that leads to a reduced receptor function. Dominant mutations of this type represent major gene effects for obesity. He participated in a lifestyle intervention program for obesity and received treatment with the selective norepinephrine re-uptake inhibitor atomoxetine for 31 months. The boy markedly reduced his BMI from 47.2 to 29.6 kg/m². <b><i>Conclusion: </i></b>Atomoxetine proved to efficiently reduce weight in a severely obese <i>MC4R</i> mutation carrier with ADHD. We briefly discuss possible mechanisms for our observation, including evidence for the functional connectivity between melanocortinergic, dopaminergic, and norepinephrinergic brain circuitries." @default.
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• W1992012100 date "2013-01-01" @default.
• W1992012100 modified "2023-10-12" @default.
• W1992012100 title "Successful Treatment with Atomoxetine of an Adolescent Boy with Attention Deficit/Hyperactivity Disorder, Extreme Obesity, and Reduced Melanocortin 4 Receptor Function" @default.
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• W1992012100 doi "https://doi.org/10.1159/000348792" @default.
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