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- W1992012316 abstract "Chikungunya virus (CHIKV) is a worldwide emerging pathogen. In humans it causes a syndrome characterized by high fever, polyarthritis, and in some cases lethal encephalitis. Growing evidence indicates that the innate immune response plays a role in controlling CHIKV infection. We show here that CHIKV induces major but transient modifications in NK-cell phenotype and function soon after the onset of acute infection. We report a transient clonal expansion of NK cells that coexpress CD94/NKG2C and inhibitory receptors for HLA-C1 alleles and are correlated with the viral load. Functional tests reveal cytolytic capacity driven by NK cells in the absence of exogenous signals and severely impaired IFN-γ production. Collectively these data provide insight into the role of this unique subset of NK cells in controlling CHIKV infection by subset-specific expansion in response to acute infection, followed by a contraction phase after viral clearance." @default.
- W1992012316 created "2016-06-24" @default.
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- W1992012316 date "2011-09-22" @default.
- W1992012316 modified "2023-10-09" @default.
- W1992012316 title "Unconventional Repertoire Profile Is Imprinted during Acute Chikungunya Infection for Natural Killer Cells Polarization toward Cytotoxicity" @default.
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- W1992012316 doi "https://doi.org/10.1371/journal.ppat.1002268" @default.
- W1992012316 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3178577" @default.
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