Matches in SemOpenAlex for { <https://semopenalex.org/work/W1992012350> ?p ?o ?g. }
- W1992012350 endingPage "148" @default.
- W1992012350 startingPage "141" @default.
- W1992012350 abstract "The proinflammatory cytokine Interleukin 1 beta (IL-1β) is elevated in obese individuals and rodents and it is implicated in impaired insulin secretion, decreased cell proliferation and apoptosis of pancreatic beta cells. In this study we describe the therapeutic effects by an IL-1β antibody to improve glucose control in hyperglycemic mice with diet-induced obesity. After 13 weeks of treatment the IL-1β antibody treated group showed reduced glycated hemoglobin (∗P = 0.049), reduced serum levels of proinsulin (∗P = 0.015), reduced levels of insulin and smaller islet size (∗P = 1.65E-13) relative to the control antibody treated group. Neutralization of IL-1β also significantly reduced serum amyloid A (SAA) which is an indicator of inflammation-induced acute phase response (∗P = 0.024). While there was no improvement of obesity, a significant improvement of glycemic control and of beta cell function is achieved by this pharmacological treatment which may slow/prevent disease progression in Type 2 Diabetes." @default.
- W1992012350 created "2016-06-24" @default.
- W1992012350 creator A5005454771 @default.
- W1992012350 creator A5034217257 @default.
- W1992012350 creator A5060149695 @default.
- W1992012350 creator A5068285710 @default.
- W1992012350 creator A5083582629 @default.
- W1992012350 creator A5086147061 @default.
- W1992012350 date "2008-10-01" @default.
- W1992012350 modified "2023-10-18" @default.
- W1992012350 title "Treatment with an Interleukin 1 beta antibody improves glycemic control in diet-induced obesity" @default.
- W1992012350 cites W1515994079 @default.
- W1992012350 cites W1758236490 @default.
- W1992012350 cites W1969036789 @default.
- W1992012350 cites W1971879246 @default.
- W1992012350 cites W1974033843 @default.
- W1992012350 cites W1980109413 @default.
- W1992012350 cites W1984026160 @default.
- W1992012350 cites W1984602007 @default.
- W1992012350 cites W1995877824 @default.
- W1992012350 cites W1996713062 @default.
- W1992012350 cites W1999734356 @default.
- W1992012350 cites W2006313514 @default.
- W1992012350 cites W2016155391 @default.
- W1992012350 cites W2021315826 @default.
- W1992012350 cites W2023535191 @default.
- W1992012350 cites W2024144587 @default.
- W1992012350 cites W2024378513 @default.
- W1992012350 cites W2031475525 @default.
- W1992012350 cites W2043566560 @default.
- W1992012350 cites W2044702322 @default.
- W1992012350 cites W2046739840 @default.
- W1992012350 cites W2049927826 @default.
- W1992012350 cites W2054135157 @default.
- W1992012350 cites W2058455617 @default.
- W1992012350 cites W2060580641 @default.
- W1992012350 cites W2060915586 @default.
- W1992012350 cites W2067863561 @default.
- W1992012350 cites W2073598149 @default.
- W1992012350 cites W2073620575 @default.
- W1992012350 cites W2076947383 @default.
- W1992012350 cites W2079477571 @default.
- W1992012350 cites W2080470702 @default.
- W1992012350 cites W2089747863 @default.
- W1992012350 cites W2091975706 @default.
- W1992012350 cites W2098906914 @default.
- W1992012350 cites W2100599316 @default.
- W1992012350 cites W2103266536 @default.
- W1992012350 cites W2104740033 @default.
- W1992012350 cites W2111742578 @default.
- W1992012350 cites W2112620654 @default.
- W1992012350 cites W2118292149 @default.
- W1992012350 cites W2119316150 @default.
- W1992012350 cites W2120522574 @default.
- W1992012350 cites W2129316761 @default.
- W1992012350 cites W2133188853 @default.
- W1992012350 cites W2135745523 @default.
- W1992012350 cites W2145534175 @default.
- W1992012350 cites W2146433754 @default.
- W1992012350 cites W2146786154 @default.
- W1992012350 cites W2148260012 @default.
- W1992012350 cites W2153117216 @default.
- W1992012350 cites W2160011392 @default.
- W1992012350 cites W2164418602 @default.
- W1992012350 cites W2171466491 @default.
- W1992012350 cites W2274037724 @default.
- W1992012350 cites W4234357566 @default.
- W1992012350 cites W4242514389 @default.
- W1992012350 cites W4243163548 @default.
- W1992012350 cites W4249627970 @default.
- W1992012350 cites W4313347845 @default.
- W1992012350 cites W4313376982 @default.
- W1992012350 doi "https://doi.org/10.1016/j.cyto.2008.07.004" @default.
- W1992012350 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3063393" @default.
- W1992012350 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18723371" @default.
- W1992012350 hasPublicationYear "2008" @default.
- W1992012350 type Work @default.
- W1992012350 sameAs 1992012350 @default.
- W1992012350 citedByCount "136" @default.
- W1992012350 countsByYear W19920123502012 @default.
- W1992012350 countsByYear W19920123502013 @default.
- W1992012350 countsByYear W19920123502014 @default.
- W1992012350 countsByYear W19920123502015 @default.
- W1992012350 countsByYear W19920123502016 @default.
- W1992012350 countsByYear W19920123502017 @default.
- W1992012350 countsByYear W19920123502018 @default.
- W1992012350 countsByYear W19920123502019 @default.
- W1992012350 countsByYear W19920123502020 @default.
- W1992012350 countsByYear W19920123502021 @default.
- W1992012350 countsByYear W19920123502022 @default.
- W1992012350 countsByYear W19920123502023 @default.
- W1992012350 crossrefType "journal-article" @default.
- W1992012350 hasAuthorship W1992012350A5005454771 @default.
- W1992012350 hasAuthorship W1992012350A5034217257 @default.
- W1992012350 hasAuthorship W1992012350A5060149695 @default.
- W1992012350 hasAuthorship W1992012350A5068285710 @default.
- W1992012350 hasAuthorship W1992012350A5083582629 @default.
- W1992012350 hasAuthorship W1992012350A5086147061 @default.