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• W1992017013 abstract "Porous monolithic columns have been prepared by the direct free radical copolymerization of glycidyl methacrylate and ethylene dimethacrylate within the confines of a 50×8 mm I.D. chromatographic column in the presence of porogens. The epoxide groups of these monoliths were modified to different extents by reaction with diethylamine to afford 1-N,N-diethylamino-2-hydroxypropyl functionalities useful for ion-exchange chromatography. Following characterization of the monoliths, the columns were tested in the chromatographic separation of a homologous series of oligodeoxyadenylic [pd(A)12–18] and oligothymidylic acids [d(pT)12–24] at different flow-rates. Very good separations of the oligonucleotides were achieved even at the high flow-rate of 4 ml/min." @default.
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• W1992017013 creator A5030055366 @default.
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• W1992017013 date "1999-08-01" @default.
• W1992017013 modified "2023-10-12" @default.
• W1992017013 title "Separation of oligonucleotides on novel monolithic columns with ion-exchange functional surfaces" @default.
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• W1992017013 doi "https://doi.org/10.1016/s0021-9673(99)00004-7" @default.
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