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- W1992017210 abstract "Vertebrate somitogenesis is a complicated process in which temporal oscillation of somite clock genes is translated into spatially periodical expression of segmentation genes. While molecular components for somite segmentation and their prospective interactions have been well documented, it is difficult to infer the spatiotemporal dynamics generated from such networks. In this study, we developed a simple mathematical model to understand the dynamics of gene regulatory network underlying segmentation process. Our model incorporated the gene regulatory network for somite segmentation in mice with the idea of “clock and wavefront model.” The model describes the dynamics of four proteins (NICD, Mesp2, Tbx6, Ripply) and two mRNAs (Mesp2, Ripply) in one dimensional array of cells, which represents a growing presomitic mesoderm. We calculate the dynamics of segmentation genes for wildtype and Ripply mutant conditions. The wildtype simulation reproduces periodic expression of NICD and Mesp2 with a subsequent degradation of Tbx6 at a future segmentation border, supporting that the modeled gene network is sufficient to explain a wildtype phenotype. In contrast, the Ripply mutant simulation fails to reproduce a mutant phenotype, indicating some unknown function of Ripply. A subsequent experiment showed a novel function of Ripply. We integrated this function into the model and confirmed that the new model reproduces both wildtype and mutant phenotypes. A comparison between two models demonstrated that the novel function of Ripply is essential for the somite segmentation." @default.
- W1992017210 created "2016-06-24" @default.
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- W1992017210 date "2010-08-01" @default.
- W1992017210 modified "2023-09-25" @default.
- W1992017210 title "Regulation of centrosome orientation in asymmetric division of the Drosophila male germ line stem cells" @default.
- W1992017210 doi "https://doi.org/10.1016/j.ydbio.2010.05.036" @default.
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